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Coverage criteria policies


These services may or may not be covered by your HealthPartners plan. Please see your plan documents for your specific coverage information. If there is a difference between this general information and your plan documents, your plan documents will be used to determine your coverage.

Administrative Process

HealthPartners Centers of Excellence
Many plans require that transplant procedures be performed at HealthPartners Transplant Centers of Excellence (COE). Some plans allow for use of non-Center of Excellence transplant facilities. Check your plan documents or contact Member Services to determine what facilities are available to you and how your choice will affect your coverage.

Please note: Cornea transplants are outside the scope of this policy. They are covered without prior notification or authorization. Cornea transplants may be received from providers outside the HealthPartners Transplant COEs .

Prior Notification/Authorization Process

For more information, please see the Related content at right for the HealthPartners Transplant Resources and COE Networks and for the transplant prior notification and authorization process and form. Submission of notification/authorization requests is required at the time of the pre-transplant evaluation and pre-transplant listing for solid organ or pre-transplant treatment for blood and marrow.

Requires prior notification

Prior notification at the time of transplant consultation is required when performed at a HealthPartners Transplant Center of Excellence (COE) for the following transplants:

  1. Kidney
  2. Heart
  3. Liver
  4. Lung
  5. Simultaneous pancreas kidney (SPK) and pancreas after kidney (PAK)
  6. Stem cell, blood and bone marrow transplants for diagnoses listed below under Indications that are Covered, #8 and #9.
Requires prior authorization

Prior authorization is required for all of the following transplants:

  1. New techniques for transplants listed above as only requiring prior notification.
  2. Any transplant at non-designated COEs (Out of Network, need for transfer, etc.)
  3. Any transplant for a diagnosis that is not listed below under Indications that are Covered, #1 through #9.
  4. Pancreas transplant alone (PTA)
  5. Small bowel transplant
  6. Multiple organ transplants
Does Not Require Prior Authorization or Prior Notification
  1. Donor Lymphocyte Infusion


Transplants are generally covered per the indications listed below and per your plan documents. The list of covered transplants is subject to periodic review and modification by the HealthPartners medical director or his or her designee.

Indications that are eligible for coverage

The following transplants are eligible for coverage:

  1. Kidney transplants for end stage disease.
  2. Heart transplants for end stage disease.
  3. Lung transplants or heart/lung transplants for:
    1. Primary pulmonary hypertension;
    2. Eisenmenger's syndrome;
    3. End stage pulmonary fibrosis;
    4. Alpha 1 antitrypsin disease;
    5. Cystic fibrosis;
    6. Emphysema.
  4. Liver transplants for:
    1. Biliary atresia in children;
    2. Primary biliary cirrhosis;
    3. Post-acute viral infection (including hepatitis A, hepatitis B antigen e negative and hepatitis C causing acute atrophy or post-necrotic cirrhosis;
    4. Primary sclerosing cholangitis;
    5. Alcoholic cirrhosis,
    6. Hepatocellular carcinoma.
  5. Pancreas transplants for simultaneous pancreas-kidney transplants for diabetes, pancreas after kidney, and living related segmental simultaneous pancreas kidney transplantation.
  6. Pancreas transplant alone (PTA) when the following indications are met:
    1. A history of frequent, acute and severe metabolic complications, such as hypoglycemia, hyperglycemia, or ketoacidosis requiring medical attention.
    2. Clinical and emotional problems with exogenous insulin therapy that are so severe as to be incapacitating, such as hypoglycemic unawareness.
    3. Consistent failure of insulin-based management to prevent acute complications.
  7. Small bowel transplantation on a case by case basis.
  8. Allogeneic bone marrow transplants or blood stem cell support (myeloablative or non-myeloablative) associated with high dose chemotherapy for:
    1. Acute lymphocytic leukemia;
    2. Chronic myelogenous leukemia;
    3. Severe combined immunodeficiency disease;
    4. Wiskott-Aldrich syndrome;
    5. Aplastic anemia;
    6. Acute myelogenous leukemia.
    7. Sickle Cell Anemia;
    8. Non-relapsed or relapsed non-Hodgkin's Lymphoma;
    9. Multiple Myeloma;
    10. Testicular cancer;
    11. Myelodysplastic syndromes associated with intermediate – very high IPSS-R scores
  9. Autologous bone marrow transplants or blood stem cell support associated with high dose chemotherapy for the following (list may not be all-inclusive):
    1. Acute leukemias;
    2. Non-Hodgkin's Lymphoma;
    3. Hodgkin's Disease;
    4. Burkitt's Lymphoma;
    5. Neuroblastoma.
    6. Multiple myeloma;
    7. Chronic myelogenous leukemia;
    8. Non relapsed non-Hodgkin's lymphoma.
    9. AL amyloidosis
  10. Donor Lymphocyte Infusion following a relapsed allogeneic bone marrow or blood stem cell transplantation.
Indications not covered

The following are not covered because they are considered experimental/investigational.

  1. Hand transplants
  2. Face transplants
  3. Uterine transplants


Autologous bone marrow or stem cell transplant refers to harvesting the bone marrow or stem cells from the patient and storing it for future use. The patient undergoes treatment including tumor ablation with high-dose chemotherapy and/or radiation. After the treatment, the bone marrow or stem cells are reinfused (transplanted) into the patient.

Allogeneic bone marrow or stem cell transplant refers to harvesting the bone marrow or stem cells from a related or unrelated donor and storing it for future use. The patient undergoes treatment including tumor ablation with high-dose chemotherapy and/or radiation. After the treatment, the bone marrow or stem cells are reinfused (transplanted) into the patient.

Transplant Center of Excellence is any health care provider, group or association of health care providers designated by HealthPartners to provide services, supplies or drugs for the specified transplant performed on a covered person. For more information, please select the link under Transplants, Related Policies titled, “Transplant Resources and COE Networks”.

Donor lymphocyte infusion (DLI) therapy is usually done after an allogeneic bone marrow transplant (BMT) has failed. The DLI procedure involves taking a blood donation from the original bone marrow or peripheral blood stem cell donor. This blood is separated and certain white cells (lymphocytes) are selected to give to the patient. The goal of the therapy is to assist in remission or recovery of the patient's bone marrow.

Transplant services include the transplant (or re-transplant) of the human organs or tissues listed below, including all related post-surgical treatment and drugs and multiple transplants for a related cause. Transplant services do not include other organ or tissue transplants or surgical implantation of mechanical devices functioning as human organs, except surgical implantation of FDA approved ventricular assist devices (VAD), functioning as a temporary bridge to heart transplantation or as destination therapy for members end stage heart failure meeting the criteria specified in the VAD coverage policy. (See the VAD policy by selecting the link under Transplants, Related Policies titled “Ventricular Assist Device- VAD”.)

If available, codes are listed below for informational purposes only, and do not guarantee member coverage or provider reimbursement. The list may not be all-inclusive.




Lung transplant, single; without cardiopulmonary bypass


Lung transplant, single; with cardiopulmonary bypass


Lung transplant, double (bilateral sequential or en bloc); without cardiopulmonary bypass


Lung transplant, double (bilateral sequential or en bloc); with cardiopulmonary bypass


Heart- lung transplant with recipient cardiectomy- pneumonectomy


Heart transplant, with or without recipient cardiectomy


Hematopoietic progenitor cell (HPC); allogeneic transplantation per donor


Hematopoietic progenitor cell (HPC); autologous transplantation


Allogeneic lymphocyte infusions


Hematopoietic progenitor cell (HPC); HPC boost


Liver allotransplantation; orthotopic, partial or whole, from cadaver or living donor, any age


Unlisted procedure, liver


Pancreatectomy, total or subtotal, with autologous transplantation of pancreas or pancreatic islet cells


Transplantation of pancreatic allograft


Unlisted procedure, pancreas


Renal allotransplantation, implantation of graft; without recipient nephrectomy


Renal allotransplantation, implantation of graft; with recipient nephrectomy


Renal autotransplantation, reimplantation of kidney


Simultaneous pancreas kidney transplantation

CPT Copyright American Medical Association. All rights reserved. CPT is a registered trademark of the American Medical Association.


This information is for most, but not all, HealthPartners plans. Please read your plan documents to see if your plan has limits or will not cover some items. If there is a difference between this general information and your plan documents, your plan documents will be used to determine your coverage. These coverage criteria may not apply to Medicare Products if Medicare requires different coverage. For more information regarding Medicare coverage criteria or for a copy of a Medicare coverage policy, contact Member Services at 952-883-7979 or 1-800-233-9645.


  1. Shanmugarajah, K, et al. Clinical outcomes of facial transplantation: A review. International Journal of Surgery, 9 (2011) 600-607.
  2. Roche NA, et al. Complex facial reconstruction by vascularized composite allotransplantation: the first Belgian case. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS, 68(3):362-71, 2015 Mar
  3. Fischer S, et al. Functional outcomes of face transplantation. American Journal of Transplantation, 15 (1) (pp 220-233) 2015 Jan
  4. Khalifian, S, et al. Facial transplantation: the first 9 years. Lancet, 13;384(9960): 2153-63 2014 Apr
  5. Van Lierde KM, et al. Speech Characteristics one year after first Belgian facial transplantation. Laryngoscope, 124(9):2021-7 2014 Sep
  6. Diaz-Siso JR, et al. Facial allotransplantation: a 3-year follow-up report. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS, 66(11):1458-63 2013 Nov
  7. Siemionow M, et al. Successes and lessons learned after more than a decade of upper extremity and face transplantation. Current Opinion in Organ Transplantation, 18(6) (pp 633-639) 2013 Dec
  8. Infante-Cossio P, et al. Facial transplantation: A concise update. Medicina Oral, Patologia Oral y Cirugia Bucal, 18(2) (ppe263-e271) 2013 Mar
  9. Järvholm s, et al. Uterus transplantation trial: Psychological evaluation of recipients and partners during the post-transplantation year. Fertil Steril. 104(4):1010-5 2015 Oct
  10. Brännström M, et al. Livebirth after uterus transplantation. Lancet, 385(9968):607-16 2015 Feb
  11. Farrell R, et al. Uterine transplant: new medical and ethical considerations. Lancet 385 (pp581-82) 2015 Feb
  12. Johannesson L, et al. Uterus transplantation trial: 1-year outcome. Fertil Steril, 103(1):199-204 2015 Jan
  13. Erman A, et al. Clinical pregnancy after uterus transplantation. Fertil Steril, 100(5): 1358-63 2013 Nov
  14. Del Priore G, et al. Uterine transplantation—a real possibility? The Indiana consensus. Human Reproduction. 28(2):288-91 2013 Feb
  15. Lantieri L, et al. Face Transplant: long-term follow-up and results of a prospective open study. The Lancet Volume 388, Issue 10052 1398-1407 2016 Jan

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Policy activity

  • 07/01/1995 - Date of origin
  • 03/01/2018 - Effective date
Review date
  • 01/2018
Revision date
  • 03/12/2018

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