Study sponsor: HealthPartners Neuroscience Center/HealthPartners Institute

Location: Neuroscience Center

Phase of Study: I

Purpose of study: Myasthenia gravis (MG) is a chronic neuromuscular, autoimmune disease characterized by muscle weakness and fatigue. Recent reviews have concluded that exercise is safe in individuals with MG, and can improve muscle strength, function, and quality of life (QOL), and reduce fatigue. The purpose of this study is to test the difference between light and moderate intensity exercise on health outcomes in people with MG. Participants will be enrolled into the NeuroWell exercise program, which is geared toward individuals with neurological disorders and led by Exercise Physiologists at the HealthPartners Neuroscience Center.

A total of 20 people with generalized MG will be enrolled in this study and participate in a small group exercise program 3 times a week for 12 weeks either in person or remote via video. Participants will be randomized into two exercise groups: 1) Light intensity or 2) Moderate intensity.

Inclusion Criteria
– Age 18-80
– Diagnosis of generalized MG
– Obtain medical clearance from the study neurologist or their physician

Exclusion Criteria
– Significant cognitive impairment of any etiology that would impact study participation
– History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion
– History of any serious neurological, psychiatric, or substance use disorders that would impact study participation.
– Women who are currently pregnant or planning to become pregnant during the study
– Any other medical conditions that could affect their ability to participate in exercise for the study duration (as determined by study investigators).
– Active participation or past participation ≤3 months in any other interventional research study

Study Contact:
Samantha Sherman
(651) 495-6367
Samantha.J.Sherman@HealthPartners.com