Principal Investigator:
Study Sponsor: Minnesota Office of Higher Education
Location: Neuroscience Center
Purpose of study: Persistent post-concussive symptoms (PPCS) involve an array of physical, cognitive, and behavioral symptoms lasting more than a month after mild traumatic brain injury (mTBI). 34-44% of people with mTBI or concussion present with a considerable burden of PPCS 3-6 months after injury. There is currently no standardized treatment for PPCS, nor FDA approved medication for any neuropsychiatric or neurocognitive symptoms associated with mTBI. Transcranial magnetic stimulation (TMS) shows promise as a treatment for PPCS. The purpose of this study is to develop and evaluate the method of personalization of TMS for PPCS and assess the feasibility and acceptability of personalized TMS for PPCS.
Inclusion Criteria:
– Clinical diagnosis of mTBI at least 4 weeks prior but not exceeding 12 months prior to the time of screening
– Age 18-65 years at the time of mTBI
– High burden of post concussive symptoms at the time of screening.
Exclusion Criteria:
– Inability to tolerate imaging; contraindication of imaging due to implants or metal.
– Seizure disorder, active alcohol or substance use disorder.
– Inability to speak and read English.
– Subject is pregnant or breast feeding
– Subject has participated in a clinical interventional trial in the last 3 months
Study Contact:
Samantha Sherman
(651) 495-6363
ClinicalTrials@HealthPartners.com
