Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease Journal Article uri icon
  • Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).

  • Link to Article
    publication date
  • 2003
  • published in
  • Neurology  Journal
  • Research
  • *Polymorphism, Genetic
  • Aged
  • Alleles
  • Arylamine N-Acetyltransferase/*genetics
  • Chromosomes, Human, Pair 8/genetics
  • Gene Frequency
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Isoenzymes/genetics
  • Parkinson Disease/*enzymology/*genetics
  • Polymorphism, Single Nucleotide/genetics
  • Risk Assessment
  • Additional Document Info
  • 60
  • issue
  • 7