Treatment with sildenafil for the healing of refractory skin ulcerations in the antiphospholipid syndrome Journal Article uri icon
  • Nonhealing skin ulceration is a cutaneous manifestation of the antiphospholipid syndrome (APS) and is associated with thrombosis of small dermal vessels. Numerous therapies have been described but are either ineffective or require a prolonged course of treatment with potential complications. We describe the efficacy of sildenafil, a phosphodiesterase inhibitor, in the treatments of such ulcers.

  • Link to Article
    publication date
  • 2003
  • published in
  • Lupus  Journal
  • Research
  • Antiphospholipid Syndrome/complications/*drug therapy
  • Phosphodiesterase Inhibitors/pharmacology/*therapeutic use
  • Piperazines/pharmacology/*therapeutic use
  • Purines
  • Sildenafil Citrate
  • Skin Ulcer/complications/*drug therapy
  • Sulfones
  • Wound Healing/*drug effects
  • Additional Document Info
  • 12
  • issue
  • 2