OBJECTIVE: This paper describes the selection of intervention activities designed to lower machine-related hazards and amputations in small metal fabrication businesses. METHODS: Methods included an advisory board, employee discussions, and pilot tests. We used a stepwise intervention mapping process to identify performance objectives, behavioral determinants, and change objectives for two target populations (business owners and employees). RESULTS: Intervention activities for owners were designed to increase knowledge about machine safety, encourage adoption of safety procedures, and motivate improvements in machine guarding. Intervention activities aimed at employees focused on building knowledge and skills of health and safety committee members. CONCLUSIONS: The intervention mapping approach led to important insights about program goals and intervention activities. Intervention mapping also ensured a systematic and thorough review of each target population in the context of our research goals.