Regions Hospital, one of the largest HealthPartners business units with its team of 5,100 dedicated professionals, is a level one trauma centre with one of the Twin Cities’ busiest Emergency Departments. The stressors related to hospital care are ever-present and the jobs are physically, emotionally, and mentally challenging. In order to deliver great care, service, and experience for patients and families, the Regions leadership team knew they had to make the health and wellbeing of employees as much a priority as the care provided to patients – because “you cannot give to others what you do not have yourself.” The Regions health and wellbeing journey started in earnest when leadership used data to identify relationships between healthcare costs and gaps in employee health. This commentary presents the Regions experience between 2009 and 2016 and highlights the key drivers and the population health impact over that period.