Actinomycosis is an infrequent infection caused by Actinomyces species bacteria. Gastric actinomycosis is extremely rare but has been identified on endoscopy, typically presenting as erythema or ulceration. Standard therapies include prolonged antibiotics, and when these fail, gastric actinomycosis often requires surgical resection. We present a case of recalcitrant gastric actinomycosis, which presented as a subepithelial lesion and the first demonstration of treatment with endoscopic resection through over-the-scope clip.