Since the publication of our integrated framework for the prevention and treatment of obesity and related chronic diseases in 2015, more than 140 Accountable Communities for Health (ACH) have been established in an effort to develop multi-sectoral partnerships to improve the health of people and their communities. All of these ACH represent potential models of integrated programs. A 2020 summit held by the Integrated Clinical and Social Systems for the Prevention and Management of Obesity Innovation Collaborative at the National Academies of Sciences, Engineering, and Medicine reviewed five case studies of such integrated programs and discussed their relevance for obesity programs. Among the five models of integration discussed, there was no consistent conceptual framework; a variety of heterogeneous factors contributed to the design of these models, including cost, self-interest, and contractual limitations. The extent to which the models mirrored the elements of the collaborative’s 2015 framework was highly variable and context-dependent. Although none of the models discussed explicitly focused on obesity, they offer insights into the adoption of integrated health and health care systems more broadly and identify some gaps and challenges that should be considered for obesity-focused integrated programs.