The lateral patellofemoral joint soft tissues contain key structures that surround and balance the joint. These structures can affect joint tracking, stability, and force distribution. It is important to understand the lateral patellofemoral anatomy and biomechanics, and their relationship with patellofemoral instability, anterior knee pain, and osteoarthritis. Lateral-sided surgical procedures such as lateral release, lateral retinacular lengthening, and partial lateral patellar facetectomy can be useful in the treatment of such patellofemoral problems.