A case of minimally progressive prodromal Alzheimer's disease Journal Article uri icon
  • Prodromal Alzheimer's disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient's neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression.

  • Link to Article
    publication date
  • 2023
  • Research
  • Alzheimer's Disease
  • Biomarkers
  • Dementia
  • Additional Document Info
  • 7
  • issue
  • 1