Lower extremity infections are a common yet unfortunate complication of diabetes-related ulcers often requiring surgical intervention. The main goals of surgical treatment consist of selecting the appropriate procedure to effectively eradicate nonsalvageable tissue, achieve primary healing, and maximize subsequent dynamic functionality. An overview of each partial foot amputation procedure is discussed with a focus on procedure selection as well as standard and advanced surgical techniques. The effective application of partial foot amputations in the high-risk diabetic population can act to minimize the need for major proximal lower limb amputations.