Amy B. Criego, MD, MS
Researcher, Medical Director of International Diabetes Center and Department Chair of Park Nicollet Pediatric Endocrinology
About

Education and training: MD, University of North Dakota, Grand Forks; Pediatric residency, DeVos Children’s Hospital, Michigan State University, Grand Rapids; Pediatric endocrinology fellowship, University of Minnesota Department of Pediatrics Division of Endocrinology; MS in science clinical research, University of Minnesota

Research interests: Primary Investigator for the Type 1 Diabetes Exchange and an investigator on Juvenile Diabetes Research Foundation and National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants to study new artificial pancreas systems and studies evaluating new medications. Involved with the collaboration between International Diabetes Center and Melrose Institute to improve care for patients with eating disorders and diabetes.

Current research activities and funding:

  • PI, CGM Intervention in Teens and Young Adults (CITY): A Randomized Clinical Trial to Assess the Efficacy and Safety of Continuous Glucose Monitoring in Young Adults 14-
  • Co PI, Home Use of MD-Logic Automated Insulin Delivery System: Safety and Efficacy (Bergenstal/Phillips): This proposed research evaluates portable/wearable technologies to measure glucose levels and adjust delivery of insulin through a promising and novel automated closed-loop artificial pancreas (AP) system called Advanced Automated Insulin Delivery System. This research project will generate the data necessary to address the safety and reliability, of this AP system and prepare the way for a grant to study a larger number of patients with this optimized closed-loop system. The 2015-2016 NIDDK funding also allow us to develop a system to easily collect, aggregate and visualize glucose data from CGM devices a component that would greatly enhance patient understanding of the effectiveness and room for improvement of his or her closed loop system. Funder: NIDDK/ UC4DK108611.
  • Co-investigator: Efficacy and Safety of Faster-acting Insulin Aspart compared to NovoRapid® Both in Combination with Insulin Degludec in Children and Adolescents with Type 1 Diabetes (NOVO 4101) (Criego): A study about the efficacy and safety of faster-acting insulin Aspart compared to NovoRapid® both in combination with insulin Degludec in children and adolescents with type 1 diabetes. (Onset 7). Funder: Novo Nordisk.
  • Co-investigator, Hybrid Closed Loop Pivotal Trial in Type 1 Diabetes: A pivotal trial to prepare for commercialization of a Medtronic hybrid closed loop system test the safety and efficacy in adolescents and adults with T1D. Funder: Medtronic.
  • PI, JAEB Type 1 Diabetes Exchange: Grant to 67 clinics to establish a systematic registry of patients with T1D in clinics across the US for research purposes and to improve clinical care. Funder: Helmsley Trust.
  • PI, Multi-Center, Prospective, Observational Study of the TS (Threshold Suspend) Feature with a Sensor-Augmented Pump System in Pediatric Patients with Type 1 Diabetes: A study investigating the threshold suspend (low-glucose suspend) feature of the Medtronic 530G system in patients ages 2-15 years. Funder: Medtronic.
Affiliation
positions
  • Research Investigator, Diabetes
  • Researcher, Medical Director of International Diabetes Center, International Diabetes Center
  • Publications
    selected publications
    Journal Article
  • How introduction of automated insulin delivery systems may influence psychosocial outcomes in adults with type 1 diabetes: findings from the first investigation with the OmnipodĀ® 5 System
    Diabetes Research and Clinical Practice. 2022
  • Safety and glycemic outcomes with a tubeless automated insulin delivery system in very young children with type 1 diabetes: a single-arm multicenter clinical trial
    Diabetes care. 2022
  • A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial
    Lancet (London, England). 2021
  • Continuous glucose monitoring integration for remote diabetes management: virtual diabetes care with case studies
    Diabetes Technology & Therapeutics. 2021
  • First outpatient evaluation of a tubeless automated insulin delivery system with customizable glucose targets in children and adults with type 1 diabetes
    Diabetes Technology & Therapeutics. 2021
  • Multicenter trial of a tubeless, on-body automated insulin delivery system with customizable glycemic targets in pediatric and adult participants with type 1 diabetes
    Diabetes care. 2021
  • Effect of continuous glucose monitoring on glycemic control in adolescents and young adults with type 1 diabetes: a randomized clinical trial
    JAMA. 2020
  • International Diabetes Center: COVID-19 won't stop us from fulfilling our mission
    Journal of Diabetes Science and Technology. 2020
  • Young children have higher variability of insulin requirements: observations during hybrid closed-loop insulin delivery
    Diabetes care. 2019
  • Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial
    Lancet (London, England). 2018
  • Time savings using a standardized glucose reporting system and ambulatory glucose profile
    Journal of Diabetes Science and Technology. 2018
  • Assessing the effectiveness of a 3-month day-and-night home closed-loop control combined with pump suspend feature compared with sensor-augmented pump therapy in youths and adults with suboptimally controlled type 1 diabetes: a randomised parallel study protocol
    BMJ open. 2017
  • The hybrid closed loop therapy system: a step closer to an artificial pancreas
    Minn Physician. 2017
  • Determining the influence of type 1 diabetes on two common eating disorder questionnaires
    Diabetes Educator. 2013
  • Characteristics of persons with an eating disorder and type 1 diabetes and psychological comparisons with persons with an eating disorder and no diabetes
    International Journal of Eating Disorders. 2012
  • Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study
    Pediatric Diabetes. 2012
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  • Amy B. Criego, MD, MS
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