Minnesota’s IIS, the Minnesota Immunization Information Connection (MIIC), was created in 2002 by the Minnesota Department of Health (MDH) from a conglomeration of many pre-existing regional registries in Minnesota. The system was established using a freely available IIS software platform developed by the Wisconsin Immunization Registry and currently used by 18 states and municipalities. MIIC earned supplemental funding from the Centers for Disease Control and Prevention (CDC) by being named one of six CDC IIS Sentinel Sites, indicating excellence in data-quality standards and evaluation of population-based data. MIIC is available at no cost to users. MIIC is used both to assist in clinical practice and to conduct epidemiologic surveillance of vaccination rates in Minnesota.