Quantitative analysis of the olfactory pathway for drug delivery to the brain Journal Article uri icon
  • Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.

  • Link to Article
    publication date
  • 1995
  • published in
  • Brain Research  Journal
  • Research
  • Animal Studies
  • Brain
  • Drugs and Drug Therapy
  • Intranasal Administration
  • Additional Document Info
  • 692
  • issue
  • 1-2