Transforming growth factor beta in Alzheimer's disease Journal Article uri icon
  • Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

  • publication date
  • 1994
  • Research
  • Alzheimer's Disease
  • Blood
  • Drugs and Drug Therapy
  • Additional Document Info
  • 1
  • issue
  • 1