Altered aspartate in Alzheimer neurofibrillary tangles Journal Article uri icon
  • Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo post-translational modification by racemization to D-aspartate, or by isomerization to the L-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a significantly greater number of these modified aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.

  • Link to Article
    publication date
  • 1992
  • published in
  • Alzheimer's Disease
  • Brain
  • Additional Document Info
  • 17
  • issue
  • 2