Description: This learning activity reviews the omega-3 fatty acids, their cardioprotective effects, role in the management of hypertriglyceridemia, recommended intake/dosage, safety, and side effects. Objectives: Following this learning activity, the learner will be able to: (1) name 3 plant sources high in a-linolenic acid and 3 marine sources high in eicosapentaenoic acid and docosahexaenoic acid; (2) discuss the American Heart Association’s recommendations for intake of omega-3 fatty acids from diet or supplements for individuals with and without known coronary heart disease and those with hypertriglyceridemia; (3) discuss how omega-3 fatty acids are believed to reduce the risk of sudden cardiac death; and (4) discuss safety and side effect issues related to the consumption of fish and fish oil supplements.