IMPORTANCE: To assess the association between degree of change in medical home transformation and the satisfaction of patients, physicians, and other staff with the experience. STUDY DESIGN: Cross-sectional surveys of lead physicians and patients. METHODS: Lead physicians in the first 108 primary care clinics in Minnesota certified as patient-centered medical homes (PCMHs) were asked about the presence and change over the past 3 years of medical home-related practice systems, as well as the job satisfaction of their physicians and staff. Patients in 54 of these clinics were surveyed using the CG-CAHPS (Clinician-Group Consumer Assessment of Healthcare Providers and Systems) questions about their experience. KEY RESULTS: The extent of change in systems over time was significantly correlated with reported positive changes in physician (0.29, P = .002) and staff (0.27, P = .005) job satisfaction, but not with the number of systems. System change was negatively correlated with patient reports of access to care (–0.43, P = .001) but unrelated to their experience with physicians and staff. CONCLUSIONS: These results add to a minimal literature on these important topics by suggesting improved physician and staff satisfaction, while highlighting the importance of the amount of change on both their satisfaction and that of patients. There may be a need to be particularly careful that medical home changes do not cause deterioration in patient access.