Lauren Crain, PhD
Sr. Research Investigator and Statistician
About

Joined the Institute: 2001

Education and training: PhD, social psychology, University of Kansas; MS, social psychology, University of California, Santa Cruz.

Overview/research interests: Psychological and social factors related to the initiation and maintenance of preventive health behavior; analysis of correlated data structures, including group-randomized interventions, repeated measures designs, and hierarchically structured observational data; and structural equation modeling.

Current research activities and funding:

  • Co-investigator on several federally funded projects focusing on preventive health behaviors, including randomized trials targeting physical activity and weight maintenance (Net-WORKS, Healthy Homes/Healthy Kids, Keep It Off, Keep Active Minnesota) and an observational study of working mothers to assess intra-individual relationships between work-family balance and preventive health behaviors
  • Co-investigator on two hierarchically structured cross-sectional surveys of academic researchers investigating relationships between perceptions of the research climate, organizational justice, and responsible conduct of research (Procedural Justice, Identity and Research Integrity; Propagating the Uniform Research Integrity Climate Assessment)
  • Co-investigator, DIAMOND Study: Evaluation of a Natural Experiment to Improve Statewide Depression Care in Minnesota, which uses staggered implementation to evaluate system-level changes in the treatment of depression in primary care clinics across Minnesota
Affiliation
positions
  • Sr. Research Investigator and Statistician, Research Methodologies Group
  • Sr. Research Investigator & Statistician, Center for Chronic Care Innovation 2001 -
    • Publications
    selected publications
    Journal Article
  • Household income, cortisol, and obesity during early childhood: a prospective longitudinal study. 
    Journal of Pediatrics. 2023
  • BestFIT Sequential Multiple Assignment Randomized Trial results: a SMART approach to developing individualized weight loss treatment sequences. 
    Annals of Behavioral Medicine. 2022
  • Cardiovascular risk for patients with and without schizophrenia, schizoaffective disorder, or bipolar disorder. 
    Journal of the American Heart Association. 2022
  • Clinician perceptions of a clinical decision support system to reduce cardiovascular risk among prediabetes patients in a predominantly rural healthcare system. 
    BMC Medical Informatics and Decision Making. 2022
  • Comparing pharmacist-led telehealth care and clinic-based care for uncontrolled high blood pressure: the Hyperlink 3 pragmatic cluster-randomized trial. 
    Hypertension (Dallas, Tex.. 2022
  • Comparison of explanatory and pragmatic design choices in a cluster-randomized hypertension trial: effects on enrollment, participant characteristics, and adherence. 
    Trials. 2022
  • Depression and cardiovascular risk in primary care patients. 
    Journal of Psychosomatic Research. 2022
  • Design of a pragmatic clinical trial to improve screening and treatment for opioid use disorder in primary care. 
    Contemporary Clinical Trials. 2022
  • Effect of clinical decision support on cardiovascular risk among adults with bipolar disorder, schizoaffective disorder, or schizophrenia: a cluster randomized clinical trial. 
    JAMA network open. 2022
  • Implementing a prediabetes clinical decision support system in a large primary care system: design, methods, and pre-implementation results. 
    Contemporary Clinical Trials. 2022
  • Race/ethnicity and age associations with hair cortisol concentrations among children studied longitudinally from early through middle childhood. 
    Psychoneuroendocrinology. 2022
  • Reach in a pragmatic hypertension trial: a critical RE-AIM component. 
    Contemporary Clinical Trials. 2022
  • A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder. 
    Addiction Science & Clinical Practice. 2021
  • Experiences and perceptions of patients with uncontrolled hypertension who are dissatisfied with their hypertension care. 
    Journal of the American Board of Family Medicine. 2021
  • Pragmatic clinic randomized trial to improve chronic kidney disease care: design and adaptation due to COVID disruptions. 
    Contemporary Clinical Trials. 2021
  • Design of a pragmatic cluster-randomized trial comparing telehealth care and best practice clinic-based care for uncontrolled high blood pressure. 
    Contemporary Clinical Trials. 2020
  • Pragmatic trial design of an intervention to reduce cardiovascular risk in people with serious mental illness. 
    Contemporary Clinical Trials. 2020
  • The Healthy Homes/Healthy Kids 5-10 Obesity Prevention Trial: 12 and 24-month outcomes. 
    Pediatric Obesity. 2019
  • Clinical decision support directed to primary care patients and providers reduces cardiovascular risk: a randomized trial. 
    Journal of the American Medical Informatics Association. 2018
  • Mediators of weight loss maintenance in the Keep It Off Trial. 
    Annals of Behavioral Medicine. 2018
  • Multicomponent obesity prevention intervention in low-income preschoolers: primary and subgroup analyses of the NET-Works Randomized Clinical Trial, 2012-2017. 
    American Journal of Public Health. 2018
  • Clinician burnout and satisfaction with resources in caring for complex patients. 
    General Hospital Psychiatry. 2017
  • Impact of a national collaborative care initiative for patients with depression and diabetes or cardiovascular disease. 
    General Hospital Psychiatry. 2017
  • The challenges of collecting and using patient care data from diverse care systems: lessons From COMPASS. 
    American Journal of Medical Quality. 2017
  • A statewide effort to implement collaborative care for depression: reach and impact for all patients with depression. 
    Medical Care. 2016
  • Predictors of poor response to depression treatment in primary care. 
    Psychiatric Services. 2016
  • The BestFIT trial: A SMART approach to developing individualized weight loss treatments. 
    Contemporary Clinical Trials. 2016
  • The effects of patient-centered depression care on patient satisfaction and depression remission. 
    Family Practice. 2016
  • A stepped-wedge evaluation of an initiative to spread the collaborative care model for depression in primary care. 
    Annals of Family Medicine. 2015
  • Activity patterns of preschool-aged children at risk for obesity. 
    Journal of physical activity & health. 2015
  • Household factors, family behavior patterns, and adherence to dietary and physical activity guidelines among children at risk for obesity. 
    Journal of Nutrition Education and Behavior. 2015
  • Organizational factors and change strategies associated with medical home transformation. 
    American Journal of Medical Quality. 2015
  • Pediatric primary care-based obesity prevention for parents of preschool children: a pilot study
    2015
  • Assessing organizational readiness for depression care quality improvement: relative commitment and implementation capability. 
    Implementation science. 2014
  • Binge eating behavior and weight loss maintenance over a 2-year period. 
    Journal of Obesity. 2014
  • Challenges of medical home transformation reported by 118 patient-centered medical home (PCMH) leaders. 
    Journal of the American Board of Family Medicine. 2014
  • Concern about child weight among parents of children at-risk for obesity
    2014
  • How much shared decision making occurs in usual primary care of depression? . 
    Journal of the American Board of Family Medicine. 2014
  • Job design and ethnic differences in working women's physical activity. 
    American Journal of Health Behavior. 2014
  • Patient experience and physician/staff satisfaction in transforming medical homes
    2014
  • Predicting child physical activity and screen time: parental support for physical activity and general parenting styles. 
    Journal of Pediatric Psychology. 2014
  • Self-reported activity and accelerometry in 2 behavior-maintenance trials. 
    American Journal of Health Behavior. 2014
  • The effect of depression treatment on work productivity. 
    American Journal of Managed Care. 2014
  • Validity of diabetes self-reports in the Women's Health Initiative. 
    Menopause (New York, N.Y.). 2014
  • Designing and implementing research on a statewide quality improvement initiative: the DIAMOND study and initiative. 
    Medical Care. 2013
  • Development and validation of the Survey of Organizational Research Climate (SORC)
    2013
  • Enhancing long-term weight loss maintenance: 2 year results from the Keep It Off randomized controlled trial. 
    Preventive Medicine. 2013
  • Healthy Homes/Healthy Kids: a randomized trial of a pediatric primary care-based obesity prevention intervention for at-risk 5-10 year olds. 
    Contemporary Clinical Trials. 2013
  • Medical home transformation: a gradual process and a continuum of attainment. 
    Annals of Family Medicine. 2013
  • Mindfulness-based stress reduction for family caregivers: a randomized controlled trial. 
    The Gerontologist. 2013
  • NET-Works: Linking families, communities and primary care to prevent obesity in preschool-age children. 
    Contemporary Clinical Trials. 2013
  • Relationships between the Survey of Organizational Research Climate (SORC) and self-reported research practices
    2013
  • Self-report compared to electronic medical record across eight adult vaccines: do results vary by demographic factors?. 
    Vaccine. 2013
  • The DIAMOND initiative: implementing collaborative care for depression in 75 primary care clinics. 
    Implementation science. 2013
  • Keep it off: a phone-based intervention for long-term weight-loss maintenance. 
    Contemporary Clinical Trials. 2011
  • Prevalence of practice system tools for improving depression care among primary care clinics: the DIAMOND initiative. 
    Journal of General Internal Medicine. 2011
  • Recruiting and retaining family caregivers to a randomized controlled trial on mindfulness-based stress reduction. 
    Contemporary Clinical Trials. 2011
  • Severity of depression and magnitude of productivity loss. 
    Annals of Family Medicine. 2011
  • The use of telehealth technology in assessing the accuracy of self-reported weight and the impact of a daily immediate-feedback intervention among obese employees. 
    International journal of telemedicine and applications. 2011
  • Maintaining physical activity among older adults: 24-month outcomes of the Keep Active Minnesota randomized controlled trial. 
    Preventive Medicine. 2010
  • Partnership research: a practical trial design for evaluation of a natural experiment to improve depression care. 
    Medical Care. 2010
  • Partnership research: a practical trial design for evaluation of a natural experiment to improve depression care. 
    Medical Care. 2010
  • Population reach and recruitment bias in a maintenance RCT in physically active older adults. 
    Journal of physical activity & health. 2010
  • The importance of organizational justice in ensuring research integrity. 
    Journal of empirical research on human research ethics. 2010
  • The long and winding road to physical activity maintenance. 
    American Journal of Health Behavior. 2010
  • Customized feedback to patients and providers failed to improve safety or quality of diabetes care: a randomized trial. 
    Diabetes care. 2009
  • Diabetes care quality: insurance, health plan, and physician group contributions. 
    American Journal of Managed Care. 2009
  • Does diabetes double the risk of depression?. 
    Annals of Family Medicine. 2009
  • Effects of paroxetine and sertraline on low-density lipoprotein cholesterol: an observational cohort study
    2009
  • Institutions' expectations for researchers' self-funding, federal grant holding, and private industry involvement: manifold drivers of self-interest and researcher behavior. 
    Academic Medicine. 2009
  • Self-weighing promotes weight loss for obese adults. 
    American Journal of Preventive Medicine. 2009
  • Telephone counseling and home telemonitoring: the Weigh by Day Trial. 
    American Journal of Health Behavior. 2009
  • A new approach to physical activity maintenance: rationale, design, and baseline data from the Keep Active Minnesota Trial. 
    BMC Geriatrics. 2008
  • Maintaining physical activity among older adults: six-month outcomes of the Keep Active Minnesota randomized controlled trial. 
    Preventive Medicine. 2008
  • The effect of advanced access implementation on quality of diabetes care. 
    Preventing Chronic Disease. 2008
  • Tobacco-use prevalence in special populations taking advantage of electronic medical records. 
    American Journal of Preventive Medicine. 2008
  • Variation in quality of diabetes care at the levels of patient, physician, and clinic. 
    Preventing Chronic Disease. 2008
  • Ambulatory care quality measures for the 6 aims from administrative data. 
    American Journal of Medical Quality. 2006
  • Care quality and implementation of the chronic care model: a quantitative study. 
    Annals of Family Medicine. 2006
  • Effect of improved primary care access on quality of depression care. 
    Annals of Family Medicine. 2006
  • Scientists' perceptions of organizational justice and self-reported misbehaviors. 
    Journal of empirical research on human research ethics. 2006
  • Health care charges associated with physical inactivity, overweight, and obesity. 
    Preventing Chronic Disease. 2005
  • Impact of an electronic medical record on diabetes quality of care. 
    Annals of Family Medicine. 2005
  • Insurance status and access to urgent ambulatory care follow-up appointments. 
    JAMA. 2005
  • Randomized trial of quality improvement intervention to improve diabetes care in primary care settings. 
    Diabetes care. 2005
  • Do all components of the chronic care model contribute equally to quality improvement?
    2004
  • Does improved access to care affect utilization and costs for patients with chronic conditions?. 
    American Journal of Managed Care. 2004
  • Health and performance factors in health care shift workers. 
    Journal of Occupational and Environmental Medicine. 2004
  • Is patient readiness to change a predictor of improved glycemic control?. 
    Diabetes care. 2004
  • Measuring patient safety in ambulatory care: potential for identifying medical group drug-drug interaction rates using claims data. 
    American Journal of Managed Care. 2004
  • Meeting recommendations for multiple healthy lifestyle factors. Prevalence, clustering, and predictors among adolescent, adult, and senior health plan members. 
    American Journal of Preventive Medicine. 2004
  • Changes in physical activity and short-term changes in health care charges: a prospective cohort study of older adults. 
    Preventive Medicine. 2003
    • Editorial Article
  • Risk and benefit information and use of aspirin [editorial]. 
    JAMA internal medicine.  177. 2017
  • Self-reported diabetes is a valid outcome in pragmatic clinical trials and observational studies [editorial]. 
    Journal of Clinical Epidemiology.  66. 2013
    • Conference Paper
  • Challenges in recruiting family caregivers to a clinical trial on MBSR (mindfulness-based stress reduction) for stress reduction
    2010
  • EHR-based clinical decision support for assessing cardiovascular risk
    2010
  • MBSR (mindfulness-based stress reduction) for caregivers of people with dementia: the Balance Study
    2010
  • Mindfulness-based stress reduction for caregivers: a randomized controlled pilot study
    2010
  • Physical activity maintenance
    2010
    • Conference Poster
  • A clinical decision support system promotes shared decision-making and cardiovascular risk factor management [poster]
    2017
  • Aspirin for primary prevention of atherosclerotic cardiovascular disease: challenges to appropriate use [poster]
    2017
  • Can prioritized clinical decision support in primary care reduce cardiovascular risk? [poster]
    2017
  • Clinical decision support impact on overuse and underuse of aspirin for primary prevention of cardiovascular events [poster]
    2017
  • Impact of improving diabetes care on Quality adjusted Life Expectancy (QALE) and costs: a 40-year perspective [poster]
    2017
  • Using EMR-linked data for passive patient safety reporting in pragmatic clinical trials [poster]
    2017
  • Design of diabetes clinical decision support systems that reduce CV risk [poster]
    2015
  • Passive safety monitoring using electronic medical records data for pragmatic cardiovascular clinical trials [poster]
    2015
  • Healthy Homes/Healthy Kids 5-10: results from baseline analyses [poster]
    2013
  • How to engage patients and clinicians as research partners, and have fun, too [poster]
    2013
  • COMPASS: evaluating an evolving and spreading innovation [poster]
    2012
  • DIAMOND: what predicts poor response to usual depression treatment in primary care? [poster]
    2012
  • Enhancing weight loss maintenance: 2 year results from the Keep It Off trial [poster]
    2012
  • Integrating patient and clinician perspectives in the TransforMN study [poster]
    2012
  • Testing a clinical decision support process to lower cardiovascular risk of patients [poster]
    2012
  • Are improvements in clinic practice systems associated with improvements in quality outcomes [poster]?
    2011
  • DIAMOND Study: an innovative observational design model for patient-centered comparative effectiveness research [poster]
    2011
  • Designing a patient interface for shared decision support [poster]
    2011
  • The DIAMOND Study [poster]
    2010
    • Abstract
  • Comparing change in systolic blood pressure with clinic-based care versus telehealth care in a pragmatic cluster-randomized trial (Hyperlink 3) [abstract]. 
    Journal of patient-centered research and reviews. 2021
  • Differences in chronic kidney disease management in patients with and without diabetes in a large care delivery system [abstract]. 
    Diabetes. 2020
  • A web-based clinical decision support system (Wizard) increases appropriate cardiometabolic diagnostic coding at primary care visits [abstract]. 
    Journal of patient-centered research and reviews. 2019
  • Dissemination and sustained use of an outpatient clinical decision system with high use rates, high clinician satisfaction, and positive impact on quality of care [abstract]. 
    Journal of patient-centered research and reviews. 2019
  • Variation in care improvement opportunities suggests need for tailored clinician-specific improvement interventions [abstract]. 
    Journal of patient-centered research and reviews. 2019
  • A comparison of the impact of the 2017 ACC/AHA hypertension guidelines on primary care populations with and without diabetes [abstract]. 
    Diabetes. 2018
  • A clinical decision support system promotes shared decision-making and cardiovascular risk factor management [abstract]. 
    Journal of patient-centered research and reviews. 2016
  • Comparative effectiveness of two diabetes clinical decision support systems on cardiometabolic outcomes and CV risk: randomized trial [abstract 2304-PUB]. 
    Diabetes. 2016
  • Design features of successful outpatient chronic disease care clinical decision support systems [abstract]. 
    Journal of patient-centered research and reviews. 2016
  • Eliciting patient treatment preferences using a clinical decision support system [abstract 1252-P]. 
    Diabetes. 2016
  • Overuse and underuse of acetyl-salicylic acid for primary prevention of cardiovascular disease in people with diabetes [abstract]. 
    Diabetologia. 2016
  • Overuse and underuse of aspirin for primary prevention [abstract 1225-P]. 
    Diabetes. 2016
  • Overuse and underuse of aspirin for primary prevention of cardiovascular events in primary care [abstract]. 
    Journal of patient-centered research and reviews. 2016
  • Randomised trial of a diabetes clinical decision support system: use rates, provider satisfaction, and impact on clinical outcomes [abstract]. 
    Diabetologia. 2016
  • The BestFIT Weight Loss Trial: smart study design and early implementation lessons learned [abstract]. 
    Annals of Behavioral Medicine. 2016
  • Achieving clinically significant weight loss: how soon can we respond to non-responders [abstract]?. 
    Annals of Behavioral Medicine. 2015
  • Evaluation of provider experience with an EHR-based clinical decision support tool [abstract]. 
    Diabetes. 2015
  • Sustained use of a diabetes clinical decision support tool in primary care practices [abstract]. 
    Diabetes. 2015
  • Testing a clinical decision support process to lower cardiovascular risk of patients [abstract]. 
    Clinical Medicine & Research. 2013
  • Changes in physical activity and nutrition in a behavioral intervention pilot study - passport to brain wellness [abstract C-A1-01]. 
    Clinical Medicine & Research. 2010
  • Comparing characteristics of adults who successfully lost weight using exercise vs. non-exercise focused methods [abstract 2511]. 
    Medicine and Science in Sports and Exercise. 2010
  • Does physical activity promote positive body image in recent weight losers [abstract]?. 
    Annals of Behavioral Medicine. 2010
  • Effect of point-of-care A1c testing in primary care clinics on diabetes medication intensification [abstract]. 
    Clinical Medicine & Research. 2010
  • Enhancing long-term weight loss maintenance: Keep It Off trial design and baseline data [abstract C-073]. 
    Annals of Behavioral Medicine. 2010
  • Racial disparities in A1c change and medication intensification [abstract PS2-20]. 
    Clinical Medicine & Research. 2010
  • The long and winding road to physical activity maintenance: theory-driven mediation analysis in the Keep Active Minnesota (KAM) trial [abstract]. 
    Annals of Behavioral Medicine. 2010
    • Document
  • Changes in cognitive function and plasma biomarkers in a pilot trial of a multi-domain intervention to prevent cognitive decline
    2010
  • Changes in physical activity and nutrition in a behavioral intervention pilot study: Passport to Brain Wellness
    2010
  • The Minnesota Memory Project
    2010
    • presentations
    Presentation
  • A partnership approach to evaluation of the implementation of a natural experiment [presentation], Seattle Implementation Research Conference (SIRC)
  • Associations between the survey of organizational research climate and self-reported research behavior [presentation], Office of Research Integrity Quest for Research Excellence Conference
  • Comparing self-report and objective measurement of physical activity in successful weight losers [presentation]
  • Control over work and time: implications for racial differences in physical activity among working mothers [presentation]
  • Demographic, child health, and parenting predictors of accelerometry wear time in preschool-aged children [presentation]
  • Development and validation of the survey of organizational research climate [presentation], Office of Research Integrity Quest for Research Excellence Conference
  • Evaluation of provider experience with an electronic health record-based clinical decision support tool [presentation], HMO Research Network (HMORN) 21st Annual Conference: Care Improvement Research: Partnering with Patients, Providers and Operational Leaders
  • Health informatics technology in diabetes care [presentation]
  • Impact of a learning healthcare network on depression outcomes: the DIAMOND initiative [presentation], NIMH (National Institute of Mental Health) 22nd Conference on Mental Health Services (MHSR), MHSR 2014: Research in Pursuit of a Mental Health Care System
  • Point-of-care prioritized clinical decision support reduces cardiovascular risk in adults with elevated cardiovascular risk: randomized trial [presentation], Conference on the Science of Dissemination and Implementation in Health, 10th Annual
  • Predictors of poor response to usual depression treatment in primary care [presentation] , HMO Research Network 20th Annual Conference: Embedded Research to Improve Health
  • Recent trends in CV risk factor control and CV risk in adults with diabetes [presentation]
  • Research design methods and problems with evaluation of implementation of a large initiative to improve primary care of depression [presentation], Global Implementation Conference
  • Sustaining use of a clinical decision support tool for primary care providers [presentation], HMO Research Network (HMORN) 21st Annual Conference: Care Improvement Research: Partnering with Patients, Providers and Operational Leaders
  • Temporal structure of work-family experiences: an ecological examination [presentation], National Council on Family Relations 74th Annual Conference
  • The TransforMN Study: background and preliminary findings [presentation], Agency for Healthcare Research & Quality (AHRQ) Annual Conference
    • Contact
    full name
  • Lauren Crain, PhD
    • primary email
  • Lauren.A.Crain@HealthPartners.com
    • located in facility
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