Karen Margolis, MD, MPH

Senior clinical investigator, director of clinical research and associate medical director for care improvement research

Academic appointment

Professor of medicine, University of Minnesota Medical School, Minneapolis; adjunct appointment, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

Joined the Institute



MD, University of Michigan; MPH, University of Minnesota, Minneapolis

Research highlights 

In addition to leading her own research studies on hypertension, Dr. Margolis has been an investigator in several large multi-center, federally funded trials involving cardiovascular disease, diabetes and women's health, including the Women's Health Initiative, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), Action to Control Cardiovascular Risk in Diabetes (ACCORD), the Aspirin in Reducing Events in the Elderly trial (ASPREE) and the Vitamin D and Type 2 Diabetes (D2d) study. Dr. Margolis has published numerous papers in medical journals such as the Journal of the American Medical Association, the New England Journal of Medicine and the Archives of Internal Medicine.

Research interests/expertise

Postmenopausal women's health, prevention of heart disease, hypertension, diabetes.

Current projects

  • Principal investigator (PI) for the National Heart, Lung and Blood Institute-funded HyperLink project to study home blood pressure telemonitoring and case management to control hypertension
  • The Women's Health Initiative
  • Aspirin in Reducing Events in the Elderly (ASPREE), a trial to test whether low-dose daily aspirin will prolong healthy lifespan in people aged 70 or older
  • Vitamin D and Type 2 Diabetes (D2d) study
  • Treatment of Hypertension in Adults with ThiaZIDES: Pragmatic Trial Pilot Study


Contact information

Office: 952-967-7301
Email: Karen.L.Margolis@HealthPartners.com