Title: Executive Director, Research
HealthPartners title: Senior Medical Director
Academic appointment: Professor of medicine, University of Minnesota Medical School, Minneapolis; adjunct appointment, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota.
Joined the Institute: 2005
Education and training: MD, University of Michigan; MPH, University of Minnesota, Minneapolis.
Overview/research interests: Prevention of heart disease, hypertension, diabetes, and postmenopausal women’s health. In addition to leading her own research studies on hypertension, Dr. Margolis has been an investigator in several large multi-center, federally funded trials involving cardiovascular disease, diabetes and women’s health, including the Women’s Health Initiative, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), Action to Control Cardiovascular Risk in Diabetes (ACCORD), the Aspirin in Reducing Events in the Elderly trial (ASPREE) and the Vitamin D and Type 2 Diabetes (D2d) study. Dr. Margolis has published numerous papers in medical journals such as the Journal of the American Medical Association, the New England Journal of Medicine and the Archives of Internal Medicine.
Current research activities and funding:
- Principal investigator (PI) for the Patient Centered Outcomes Research Institute-funded HyperLink project to compare telehealth and clinic-based care for uncontrolled high blood pressure
- BP-Check, a trial comparing different methods to diagnose hypertension
- Aspirin in Reducing Events in the Elderly (ASPREE), a trial to test whether low-dose daily aspirin will prolong healthy lifespan in people aged 70 or older. The trial has been completed and a five-year observational study is in progress.
- Vitamin D and Type 2 Diabetes (D2d), a recently completed trial comparing vitamin D and placebo for preventing diabetes in patients with prediabetes
- INVESTED trial comparing two formulations of influenza vaccine in patients with heart disease
- The Women’s Health Initiative