Nasal delivery of lidocaine decreases carrageenan-induced orofacial pain [poster] Conference Poster uri icon
  • Objectives: Intranasal lidocaine has been demonstrated to target the trigeminal nerve and decrease trigeminal neuralgia pain in humans. This study used a novel behavior apparatus to assess the effect of intranasal lidocaine in a rat model of carrageenan-induced orofacial pain.
    Methods: The TrigeminAir behavior apparatus was used, which is designed to present air pressure on the sensitized, carrageenan-inflamed whisker pad and electronically measure sip rate of a sweetened condensed milk reward. A computer continuously recorded sip rate for six rats simultaneously.
    Results: Increased doses of carrageenan (0%, 2%, and 4%) resulted in decreased sip rate (p<0.01) in the TrigeminAir from 5 to 12 hours post-carrageenan injection. Intranasal 10% lidocaine reversed (p<0.05) the effects of carrageenan on sip rate compared to intranasal 0% lidocaine.
    Conclusions: These results along with previously published evidence indicate that intranasal lidocaine is an effective trigeminal nerve block to orofacial structures. TrigeminAir is a novel method of screening for orofacial pain models and treatments in rats, particularly trigeminal neuralgia.

  • publication date
  • 2011
  • Research
  • Animal Studies
  • Dental Care
  • Drugs and Drug Therapy
  • Intranasal Administration
  • Pain