Leah R. Hanson, PhD
Senior Director, Neuroscience Research, and Senior Investigator, HealthPartners Institute
About

Education and training: PhD, neuroscience, University of Minnesota, Minneapolis.

Overview/research interests: The prevention and treatment of Alzheimer’s disease and other neurodegenerative disorders; how lifestyle changes, including exercise of the body and mind, can prevent memory loss associated with aging.

Current research activities and funding: The Minnesota Memory Project.

Overview
geographic focus
  • Minnesota  State or Province
  • Affiliation
    positions
    Publications
    selected publications
    Journal Article
  • A phase II, single-center, randomized, double-blind, placebo-controlled study of the safety and therapeutic efficacy of intranasal glulisine in amnestic mild cognitive impairment and probable mild Alzheimer's disease
    Drugs and Aging. 2021
  • Barriers to achieving target door-to-needle time in patients treated with IV thrombolysis
    Healthc Res J. 2021
  • Losartan improves memory, neurogenesis and cell motility in transgenic Alzheimer's mice
    Pharmaceuticals (Basel, Switzerland). 2021
  • Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations
    Translational psychiatry. 2021
  • Double-blind placebo-controlled pilot investigation of the safety of a single dose of rapid-acting intranasal insulin in Down syndrome
    Drugs in R&D. 2020
  • Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non-disease-specific pathway of functional neurologic improvement
    Brain and behavior. 2020
  • Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson's Disease
    Neuroscience Letters. 2020
  • Transforming dementia care through pragmatic clinical trials embedded in learning healthcare systems
    Journal of the American Geriatrics Society. 2020
  • Feasibility trial of a 10-week adaptive yoga intervention developed for chronic pain patients
    Pain Management Nursing. 2019
  • From A to D: a unique case report of recovery after longitudinal myelitis related to lupus
    American Journal of Physical Medicine and Rehabilitation. 2019
  • Intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats
    Journal of Pharmacology and Experimental Therapeutics. 2019
  • Quantifying intranasally administered deferoxamine in rat brain tissue with mass spectrometry
    ACS Chemical Neuroscience. 2019
  • Solitary bone plasmacytoma compression injury disguised as back pain: a case report
    2019
  • Unique case report of a meningeal sarcoma arising during ongoing treatment for progressing intraparenchymal glioma
    2019
  • Pharmacokinetics in rat of P8, a peptide drug candidate for the treatment of Alzheimer's disease: stability and delivery to the brain
    Journal of Alzheimer's disease reports. 2018
  • Rescue therapies for seizure emergencies: new modes of administration
    Epilepsia. 2018
  • Screening positive for cognitive impairment: impact on healthcare utilization and provider action in primary and specialty care practices
    Journal of General Internal Medicine. 2018
  • Intranasal adeno-associated virus mediated gene delivery and expression of human iduronidase in the central nervous system: a noninvasive and effective approach for prevention of neurologic disease in mucopolysaccharidosis Type I
    Human Gene Therapy. 2017
  • Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease
    Journal of the Neurological Sciences. 2017
  • Intranasal delivery of a novel amnion cell secretome prevents neuronal damage and preserves function in a mouse multiple sclerosis model
    Scientific Reports. 2017
  • Oxytocin enhances observational fear in mice
    Nature communications. 2017
  • Research priorities to advance the health and health care of older adults with multiple chronic conditions
    Journal of the American Geriatrics Society. 2017
  • Food consumption and activity levels increase in rats following intranasal Hypocretin-1
    Neuroscience Letters. 2016
  • Routine cognitive screening in a neurology practice: effect on physician behavior
    2016
  • Can biomarkers differentiate pain and no pain subgroups of nonverbal children with cerebral palsy? A preliminary investigation based on noninvasive saliva sampling
    Pain Medicine. 2015
  • Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation
    Neuroscience Letters. 2015
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    Neuroscience. 2014
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    Molecular Pain. 2014
  • A single-dose pilot trial of intranasal rapid-acting insulin in apolipoprotein e4 carriers with mild-moderate Alzheimer's disease
    2014
  • Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinsons disease
    Brain Research. 2014
  • Intranasal administration of CNS therapeutics to awake mice
    Journal of visualized experiments. 2013
  • Mindfulness-based stress reduction for family caregivers: a randomized controlled trial
    The Gerontologist. 2013
  • Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states:
    Molecular Pain. 2012
  • Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1alpha, and phosphorylates GSK3beta in P301L tau transgenic mice
    Experimental Brain Research. 2012
  • Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice
    Drug delivery and translational research. 2012
  • Intranasal delivery of growth differentiation factor 5 to the central nervous system
    Drug delivery. 2012
  • Intranasal delivery of insulin via the olfactory nerve pathway
    Journal of Pharmacy and Pharmacology. 2012
  • Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway
    Neuroscience Letters. 2012
  • Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration
    Molecular Genetics and Metabolism. 2012
  • Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats
    Neurobiology of Disease. 2012
  • Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice
    Journal of Molecular Neuroscience. 2011
  • Motor end plate innervation loss in diabetes and the role of insulin
    Journal of Neuropathology and Experimental Neurology. 2011
  • Recruiting and retaining family caregivers to a randomized controlled trial on mindfulness-based stress reduction
    Contemporary Clinical Trials. 2011
  • Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS
    Journal of Drug Targeting. 2010
  • Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
    Rejuvenation research. 2010
  • Trigeminal pathways deliver a low molecular weight drug from the nose to the brain and orofacial structures
    Molecular Pharmaceutics. 2010
  • Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke
    Journal of Pharmacology and Experimental Therapeutics. 2009
  • Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system
    Journal of Pharmaceutical Sciences. 2009
  • Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system
    Journal of Pharmacology and Experimental Therapeutics. 2009
  • Delivery of interferon-beta to the monkey nervous system following intranasal administration
    Neuroscience. 2008
  • Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis
    Journal of Neuroimmunology. 2004
  • The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats
    Journal of Stroke and Cerebrovascular Diseases. 2004
  • Editorial Article
    Conference Poster
  • Outcomes of an embedded resource and education program for patients and families with memory loss [poster]
    2017
  • Performance on cognitive screening is associated with increased retrospective healthcare utilization [poster]
    2015
  • Pharmacokinetics of a diazepam prodrug/enzyme combination following nasal administration in rats for treatment of seizure emergencies [poster]
    2015
  • Routine cognitive screening in a neurology practice: impact on physician behavior [poster]
    2015
  • The Minnesota Memory Project: baseline data from a longitudinal observational study of aging [poster]
    2015
  • Failure on cognitive screening predicts increased healthcare utilization [poster]
    2014
  • Routine cognitive screening in a general neurology clinic: impact on physician behavior [poster]
    2014
  • Detection of deferoxamine using liquid chromatography/mass spectrometry with electrospray ionization [poster]
    2013
  • Intranasally administered deferoxamine induces neuroprotection in a 6-OHDA model of Parkinson's disease [poster]
    2013
  • Lavender essential oil improved sleep in residents of a memory care assisted living facility [poster]
    2013
  • The effect of intranasal rapid acting insulin on ApoE4 carriers with mild-moderate Alzheimer's disease [poster]
    2013
  • Feasibility of the mini-cog as a standardized cognitive screen in HealthPartners patients aged 70 and older [poster]
    2012
  • Intranasal deferoxamine treatment in a rat model of Parkinsons disease: preliminary results [poster]
    2012
  • Pedicle screw fixation in cervical trauma [poster]
    2012
  • Specific types of memory complaints may provide an early warning sign of cognitive impairment in community dwelling older adults [poster]
    2012
  • The 6th Vital Sign Project: does cognitive screening in the elderly population improve clinical care [poster]?
    2012
  • Tractography of the human cervical spine nerve roots [poster]
    2012
  • Nasal delivery of lidocaine decreases carrageenan-induced orofacial pain [poster]
    2011
  • Abstract
  • IMPACT Learning Health Network: transforming care through embedded pragmatic clinical trials in health care settings that serve people with dementia [abstract]
    Journal of patient-centered research and reviews. 2021
  • The NIA IMPACT Collaboratory: transforming dementia care rhrough embedded pragmatic clinical trials [abstract]
    2020
  • Implementation of a mindfulness based dementia-care program within a healthcare system [abstract]
    Innovation in aging. 2019
  • Chord Study: the power of music through participation in the giving voice chorus [abstract]
    Alzheimer's & dementia. 2018
  • Correlation between evaluation and documentation of neurologic deficit by EMS and ED of patients with acute ischemic stroke [abstract]
    Neurology. 2018
  • Analysis of run sheets of EMS serving a metropolitan comprehensive stroke center [abstract]
    Neurology. 2017
  • Clinical characteristics and healthcare utilization of Hmong patients presenting with stroke [abstract]
    Neurology. 2017
  • Clinical characteristics of Hmong patients presenting with acute ischemic stroke [abstract]
    Stroke. 2017
  • Cognitive screening results from the Medicare annual wellness visit in a primary care practice [abstract]
    Alzheimer's & dementia. 2017
  • Mindfulness for early Alzheimer's Disease: a pilot study [abstract]
    Alzheimer's & dementia. 2017
  • Minnesota memory project: use of the Alberta Smell Test in a longitudinal aging cohort [abstract]
    Alzheimer's & dementia. 2016
  • Outcomes from routine cognitive screening in a health care system [abstract]
    Alzheimer's & dementia. 2016
  • Outcomes of a dementia resource and education program imbedded in a health care system [abstract]
    Alzheimer's & dementia. 2016
  • Delivery of therapeutics via the intranasal route for the treatment of neurodegenerative diseases [abstract]
    Neurotherapeutics. 2015
  • Contact
    full name
  • Leah R. Hanson, PhD
  • primary email
  • Leah.R.Hanson@healthpartners.com
  • located in facility

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