Marini, John J., MD
Director of Physiological and Translational Research, Regions Hospital

selected publications

• Journal Article

  • A more gradual positive end-expiratory pressure increase reduces lung damage and improves cardiac function in experimental acute respiratory distress syndrome.  Journal of applied physiology (Bethesda, Md.. 2022
  • Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia.  Intensive Care Medicine. 2022
  • Reliable estimates of power delivery during mechanical ventilation utilizing easily obtained bedside parameters.  Respiratory Care. 2022
  • Dorsal push and abdominal binding improve respiratory compliance and driving pressure in proned coronavirus disease 2019 acute respiratory distress syndrome.  Critical care explorations. 2021
  • Elastic power of mechanical ventilation in morbid obesity and severe hypoxemia.  Respiratory Care. 2021
  • Intra-cycle power: is the flow profile a neglected component of lung protection?.  Intensive Care Medicine. 2021
  • Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury.  Intensive care medicine experimental. 2021
  • Paradoxically improved respiratory compliance with abdominal compression in COVID-19 ARDS.  Chest. 2021
  • Prevalence and outcome of silent hypoxemia in COVID-19.  Minerva Anestesiologica. 2021
  • Role of total lung stress on the progression of early COVID-19 pneumonia.  Intensive Care Medicine. 2021
  • The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome.  Respiratory Research. 2021
  • "Less is More" in mechanical ventilation.  Intensive Care Medicine. 2020
  • Does iso-mechanical power lead to iso-lung damage: an experimental study in a porcine model.  Anesthesiology. 2020
  • Elastic power but not driving power is the key promoter of ventilator-induced lung injury in experimental acute respiratory distress syndrome.  Critical Care (London, England). 2020
  • Estimating the damaging power of high-stress ventilation.  Respiratory Care. 2020
  • Management of COVID-19 respiratory distress.  JAMA. 2020
  • Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study.  Intensive Care Medicine. 2020
  • Time course of evolving ventilator-induced lung injury: the "shrinking baby lung".  Critical Care Medicine. 2020
  • What have we learned from animal models of ventilator-induced lung injury?.  Intensive Care Medicine. 2020
  • Driving pressure: defining the range.  Respiratory Care. 2019
  • Gradually increasing tidal volume may mitigate experimental lung injury in rats.  Anesthesiology. 2019
  • Positive end-expiratory pressure and mechanical power.  Anesthesiology. 2019
  • Understanding lactatemia in human sepsis. Potential impact for early management.  American Journal of Respiratory and Critical Care Medicine. 2019
  • Conditional hemodynamic tolerance to decremental recruitment of the "open lung".  Critical Care Medicine. 2018
  • Energetics and the root mechanical cause for ventilator-induced lung injury.  Anesthesiology. 2018
  • PEEP titration: the effect of prone position and abdominal pressure in an ARDS model.  Intensive care medicine experimental. 2018
  • Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis.  Intensive care medicine experimental. 2018
  • Protecting the ventilated lung: vascular surge and deflation energetics.  American Journal of Respiratory and Critical Care Medicine. 2018
  • Evidence or belief-based medicine? Ten doubts.  Intensive Care Medicine. 2017
  • Reliability of transpulmonary pressure-time curve profile to identify tidal recruitment/hyperinflation in experimental unilateral pleural effusion.  Journal of Clinical Monitoring and Computing. 2017
  • Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016.  Intensive Care Medicine. 2017
  • Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016.  Critical Care Medicine. 2017
  • Fast versus slow recruitment maneuver at different degrees of acute lung inflammation induced by experimental sepsis.  Anesthesia and Analgesia. 2016
  • Strain rate and cycling frequency-The "dynamic duo" of injurious tidal stress.  Critical Care Medicine. 2016
  • The effect of compartmental asymmetry on the monitoring of pulmonary mechanics and lung volumes.  Respiratory Care. 2016
  • Biological impact of transpulmonary driving pressure in experimental acute respiratory distress syndrome.  Anesthesiology. 2015
  • Critical care evidence--new directions.  JAMA. 2015
  • Diaphragm ultrasound as indicator of respiratory effort in critically ill patients undergoing assisted mechanical ventilation: a pilot clinical study.  Critical Care (London, England). 2015
  • Impact of chest wall modifications and lung injury on the correspondence between airway and transpulmonary driving pressures.  Critical Care Medicine. 2015
  • The top attributes of excellence of intensive care physicians.  Intensive Care Medicine. 2015
  • Development of a lethal, closed-abdomen, arterial hemorrhage model in noncoagulopathic swine.  Journal of Surgical Research. 2014
  • Drainage of pleural effusion in mechanically ventilated patients: time to measure chest wall compliance?.  Journal of Critical Care. 2014
  • Positional effects on lung volumes and transpulmonary pressure during unilateral mechanical asymmetry.  Minnesota Medicine. 2014
  • Self-expanding foam for prehospital treatment of intra-abdominal hemorrhage: 28-day survival and safety.  The journal of trauma and acute care surgery. 2014
  • Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study.  The journal of trauma and acute care surgery. 2014
  • Self-expanding foam improves survival following a lethal, exsanguinating iliac artery injury.  The journal of trauma and acute care surgery. 2014
  • Unilateral mechanical asymmetry. Positional effects on lung volumes and transpulmonary pressure.  Intensive care medicine experimental. 2014
  • Experimental intra-abdominal hypertension influences airway pressure limits for lung protective mechanical ventilation.  The journal of trauma and acute care surgery. 2013
  • Recruitment maneuvers modulate epithelial and endothelial cell response according to acute lung injury etiology.  Critical Care Medicine. 2013
  • Under pressure.  Annals of the American Thoracic Society. 2013
  • Value and limitations of transpulmonary pressure calculations during intra-abdominal hypertension.  Critical Care Medicine. 2013
  • Ventilator-associated problems related to obstructive lung disease.  Respiratory Care. 2013
  • Experimental intra-abdominal hypertension attenuates the benefit of positive end-expiratory pressure in ventilating effusion-compressed lungs*.  Critical Care Medicine. 2012
  • Dynamic hyperinflation and auto-positive end-expiratory pressure: lessons learned over 30 years.  American Journal of Respiratory and Critical Care Medicine. 2011
  • Impact of pressure profile and duration of recruitment maneuvers on morphofunctional and biochemical variables in experimental lung injury.  Critical Care Medicine. 2011
  • Non-pulmonary factors strongly influence the stress index.  Intensive Care Medicine. 2011
  • Pleural effusion complicates monitoring of respiratory mechanics.  Critical Care Medicine. 2011
  • Point: Is pressure assist-control preferred over volume assist-control mode for lung protective ventilation in patients with ARDS? Yes.  Chest. 2011
  • Recruitment by sustained inflation: time for a change.  Intensive Care Medicine. 2011
  • Spontaneously regulated vs. controlled ventilation of acute lung injury/acute respiratory distress syndrome.  Current Opinion in Critical Care. 2011
  • Agreement between functional residual capacity estimated via automated gas dilution versus via computed tomography in a pleural effusion model.  Respiratory Care. 2010
  • Can we prevent the spread of focal lung inflammation?.  Critical Care Medicine. 2010
  • Cardiovascular and metabolic effects of high-dose insulin in a porcine septic shock model.  Academic Emergency Medicine. 2010
  • Prone positioning for ARDS: defining the target.  Intensive Care Medicine. 2010
  • Safer ventilation of the injured lung: one step closer.  Critical Care (London, England). 2010
  • Thermal therapeutics: the importance of good timing.  Anesthesia and Analgesia. 2010
  • Thirty years of critical care medicine.  Critical Care (London, England). 2010
  • Acoustic monitoring--super sonics?.  Critical Care (London, England). 2009
  • Acute coronary thrombosis in a patient with septic shock without any evidence of disseminated intravascular coagulation.  BMJ Case Reports. 2009
  • Airway pressure release ventilation.  Journal of burn care & research. 2009
  • High dose insulin in toxic cardiogenic shock.  Clinical Toxicology (Philadelphia, Pa.). 2009
  • Semi-quantitative tracking of intra-airway fluids by computed tomography.  Clinical Physiology and Functional Imaging. 2009
  • Cigarettes-induced acute eosinophilic pneumonia: a case report 2008
  • Do airway secretions play an underappreciated role in acute respiratory distress syndrome?.  Current Opinion in Critical Care. 2008
  • How best to recruit the injured lung?.  Critical Care (London, England). 2008
  • Lung injury--settle for a sketch or design a blueprint?.  Critical Care Medicine. 2008
  • Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome.  American Journal of Respiratory and Critical Care Medicine. 2008
  • Meta-analysis: convenient assumptions and inconvenient truth.  Critical Care Medicine. 2008
  • Propagation prevention: a complementary mechanism for "lung protective" ventilation in acute respiratory distress syndrome.  Critical Care Medicine. 2008
  • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.  Critical Care Medicine. 2008
  • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.  Intensive Care Medicine. 2008
  • The pulmonary artery catheter: in medio virtus.  Critical Care Medicine. 2008
  • Ventilation patterns influence airway secretion movement.  Respiratory Care. 2008
  • The "open lung" compromise.  Intensive Care Medicine. 2007
  • Time course of physiologic variables in response to ventilator-induced lung injury.  Respiratory Care. 2007
  • A proposed curvilinearity index for quantifying airflow obstruction.  Respiratory Care. 2006
  • Limitations of clinical trials in acute lung injury and acute respiratory distress syndrome.  Current Opinion in Critical Care. 2006
  • Advances in the understanding of acute respiratory distress syndrome: summarizing a decade of progress.  Current Opinion in Critical Care. 2004
  • Effects of ventilatory pattern on experimental lung injury caused by high airway pressure.  Critical Care Medicine. 2004
  • Intercomparison of recruitment maneuver efficacy in three models of acute lung injury.  Critical Care Medicine. 2004
  • Partitioning the work-sparing effects of partial ventilatory support in airflow obstruction.  Critical Care (London, England). 2004
  • Reluctant horses at the digital river.  Critical Care (London, England). 2004
  • Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injury.  Critical Care Medicine. 2004
  • Ventilatory management of acute respiratory distress syndrome: a consensus of two.  Critical Care Medicine. 2004
  • Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injury.  Critical Care (London, England). 2003
  • Distal projection of insufflated gas during tracheal gas insufflation.  Journal of applied physiology (Bethesda, Md.. 2002
  • Oscillations and noise: inherent instability of pressure support ventilation?.  American Journal of Respiratory and Critical Care Medicine. 2002
  • Pulmonary microvascular fracture in a patient with acute respiratory distress syndrome.  Critical Care Medicine. 2002
  • Tracheal gas insufflation during late exhalation efficiently reduces PaCO(2) in experimental acute lung injury.  Intensive Care Medicine. 2002
  • Ventilation of patients with asthma and chronic obstructive pulmonary disease.  Current Opinion in Critical Care. 2002
  • Dynamic behavior during noninvasive ventilation: chaotic support?.  American Journal of Respiratory and Critical Care Medicine. 2001
  • Relative roles of vascular and airspace pressures in ventilator-induced lung injury.  Critical Care Medicine. 2001
  • Static and dynamic pressure-volume curves reflect different aspects of respiratory system mechanics in experimental acute respiratory distress syndrome.  Respiratory Care. 2001
  • Prone positioning attenuates and redistributes ventilator-induced lung injury in dogs.  Critical Care Medicine. 2000
  • Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange.  American Journal of Respiratory and Critical Care Medicine. 2000

• Editorial Article

  • "Established" respiratory treatment in acute respiratory distress syndrome: scientific rigor or a square peg in a round hole [editorial]?.  American Journal of Respiratory and Critical Care Medicine.  203. 2021
  • COVID-19 and ARDS: the baby lung size matters [editorial].  Intensive Care Medicine.  47. 2021
  • Complexity and unanswered questions in the pathophysiology of COVID-19 ARDS [editorial].  Intensive Care Medicine.  47. 2021
  • Conceptual simplicity in pursuit of precision [editorial].  Intensive Care Medicine.  47. 2021
  • Isn't it time to abandon ARDS? The COVID-19 lesson [editorial].  Critical Care (London, England).  25. 2021
  • Pathophysiology of COVID-19-associated acute respiratory distress syndrome [editorial].  The Lancet. Respiratory medicine.  9. 2021
  • Reply to Tobin: Respiratory drive measurements do not signify conjectural patient self-inflicted lung injury [editorial].  American Journal of Respiratory and Critical Care Medicine.  203. 2021
  • Smoothing the edges of lung protection [editorial].  American Journal of Respiratory and Critical Care Medicine.  203. 2021
  • The 4DPRR Index and mechanical power: a step ahead or four steps backward [editorial]?.  American Journal of Respiratory and Critical Care Medicine.  204. 2021
  • COVID-19 phenotypes: leading or misleading [editorial]?.  European Respiratory Journal.  56. 2020
  • COVID-19: scientific reasoning, pragmatism and emotional bias [editorial].  Annals of intensive care.  10. 2020
  • Dealing with the CARDS of COVID-19 [editorial].  Critical Care Medicine.  48. 2020
  • Finding best PEEP: a little at a time [editorial].  Respiratory Care.  65. 2020
  • Hysteresis as an indicator of recruitment and ventilator-induced lung injury risk [editorial].  Critical Care Medicine.  48. 2020
  • Integrating the evidence: confronting the COVID-19 elephant [editorial].  Intensive Care Medicine.  46. 2020
  • Recruiting the acutely injured lung: how and why [editorial]?.  American Journal of Respiratory and Critical Care Medicine.  201. 2020
  • Spontaneous breathing, transpulmonary pressure and mathematical trickery [editorial].  Annals of intensive care.  10. 2020
  • The baby lung and the COVID-19 era [editorial].  Intensive Care Medicine.  46. 2020
  • The respiratory drive: an overlooked tile of COVID-19 pathophysiology [editorial].  American Journal of Respiratory and Critical Care Medicine.  202. 2020
  • Which component of mechanical power is most important in causing VILI [editorial]?.  Critical Care (London, England).  24. 2020
  • The tidal volume fix [editorial]?.  Journal of Thoracic Disease.  11. 2019
  • Conditional value of raising positive end-expiratory pressure to counter vigorous breathing efforts in injured lungs [editorial].  American Journal of Respiratory and Critical Care Medicine.  197. 2018
  • Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No [editorial].  Intensive Care Medicine.  44. 2018
  • Firmer footing for ventilating and monitoring the injured lung [editorial].  Journal of Thoracic Disease.  10. 2018
  • Should we titrate positive end-expiratory pressure based on an end-expiratory transpulmonary pressure [editorial]?.  Annals of translational medicine.  6. 2018
  • Time to rethink the approach to treating acute respiratory distress syndrome [editorial].  JAMA.  319. 2018
  • Volutrauma and atelectrauma: which is worse [editorial]?.  Critical Care (London, England).  22. 2018
  • Clinical deployment of the esophageal balloon catheter-making the case [editorial].  Critical Care Medicine.  45. 2017
  • Transpulmonary pressure meaning: Babel or conceptual evolution [editorial]?.  American Journal of Respiratory and Critical Care Medicine.  195. 2017
  • Dynamic predictors of VILI risk: beyond the driving pressure [editorial].  Intensive Care Medicine.  42. 2016
  • Should we embrace the "open lung" approach [editorial]?.  Critical Care Medicine.  44. 2016
  • Does high-pressure, high-frequency oscillation shake the foundations of lung protection [editorial]?.  Intensive Care Medicine.  41. 2015
  • Prone positioning and neuromuscular blocking agents are part of standard care in severe ARDS patients: we are not sure [editorial].  Intensive Care Medicine.  41. 2015
  • Introduction (foreword) to the issue. Heart and lung monitoring [editorial].  Current Opinion in Critical Care.  20. 2014
  • Mid-frequency ventilation: a viable option for lung protection [editorial]?.  Respiratory Care.  59. 2014
  • Spontaneous breathing, extrapulmonary CO(2) removal, and ventilator-induced lung injury risk: less power to the people [editorial]?.  Critical Care Medicine.  42. 2014
  • Lower tidal volumes for everyone: principle or prescription [editorial]?.  Intensive Care Medicine.  39. 2013
  • Monitoring breathing effort: a work in progress [editorial].  Critical Care Medicine.  41. 2013
  • Position, positive end-expiratory pressure, and obstructive obesity [editorial].  Critical Care Medicine.  41. 2013
  • Too much for too long-wrong targets, wrong timing [editorial]?.  Critical Care Medicine.  41. 2013
  • Transpulmonary pressure as a surrogate of plateau pressure for lung protective strategy: not perfect but more physiologic [editorial].  Intensive Care Medicine.  38. 2012
  • Does positive end-expiratory pressure improve CO(2) exchange in controlled ventilation of acute airflow obstruction [editorial]?.  Critical Care Medicine.  39. 2011
  • Risk factors associated with early reintubation in trauma patients: a prospective observational study [invited editorial].  Journal of Trauma.  71. 2011

• Chapter

  • Ventilatory management of obstructive airway disease.  Critical care medicine: principles of diagnosis and management in the adult. 2014
  • Position and the compromised respiratory system.  Annual update in intensive care and emergency medicine. 2012

• Conference Poster

  • Experimental intra-abdominal pressure symmetrically influences bladder pressure and airway plateau pressure [poster] 2012

• Review

  • COVID-19 pneumonia: pathophysiology and management [review].  European Respiratory Review: An Official Journal of the European Respiratory Society. 2021
  • Improving lung compliance by external compression of the chest wall [review].  Critical Care (London, England). 2021
  • Personalized mechanical ventilation in acute respiratory distress syndrome [review].  Critical Care (London, England). 2021
  • Extracorporeal membrane oxygenation for respiratory failure [review].  Anesthesiology. 2020
  • Prone position in ARDS patients: why, when, how and for whom [review].  Intensive Care Medicine. 2020
  • Static and dynamic contributors to ventilator-induced lung injury in clinical practice. Pressure, energy, and power [review].  American Journal of Respiratory and Critical Care Medicine. 2020
  • Acute lobar atelectasis [review].  Chest. 2019
  • Evolving concepts for safer ventilation [review].  Critical Care (London, England). 2019
  • Dissipation of energy during the respiratory cycle: conditional importance of ergotrauma to structural lung damage [review].  Current Opinion in Critical Care. 2018
  • Physiology-guided management of hemodynamics in acute respiratory distress syndrome [review].  Annals of translational medicine. 2018
  • Management of critical burn injuries: recent developments [review] 2017
  • Respiratory support in patients with acute respiratory distress syndrome: an expert opinion [review].  Critical Care (London, England). 2017
  • Seven unconfirmed ideas to improve future ICU practice [review].  Critical Care (London, England). 2017
  • The future of mechanical ventilation: lessons from the present and the past [review].  Critical Care (London, England). 2017
  • The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation [review].  Intensive Care Medicine. 2017
  • Time-sensitive therapeutics [review].  Critical Care (London, England). 2017
  • Excellence in intensive care medicine [review].  Critical Care Medicine. 2016
  • Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation [review].  Intensive Care Medicine. 2016
  • Is automated weaning superior to manual spontaneous breathing trials [review]?.  Respiratory Care. 2016
  • Should early prone positioning be a standard of care in ARDS with refractory hypoxemia [review]?.  Respiratory Care. 2016
  • The "baby lung" became an adult [review].  Intensive Care Medicine. 2016
  • Lung recruitment in acute respiratory distress syndrome: what is the best strategy [review]?.  Current Opinion in Critical Care. 2014
  • Mechanical ventilation: past lessons and the near future [review].  Critical Care (London, England). 2013
  • Our favorite unproven ideas for future critical care [review].  Critical Care (London, England). 2013
  • Prone position in acute respiratory distress syndrome. Rationale, indications, and limits [review].  American Journal of Respiratory and Critical Care Medicine. 2013
  • Two steps forward in bedside monitoring of lung mechanics: transpulmonary pressure and lung volume [review].  Critical Care (London, England). 2013
  • Unproven clinical evidence in mechanical ventilation [review].  Current Opinion in Critical Care. 2012
  • Update: adjuncts to mechanical ventilation [review].  Current Opinion in Anaesthesiology. 2012

• Abstract

  • How does IAP affect esophageal pressure [abstract]?.  American Journal of Respiratory and Critical Care Medicine. 2013
  • Fowler's position reduces effusion-caused compressive lung stress and increases functional residual capacity [abstract].  American Journal of Respiratory and Critical Care Medicine. 2012
  • Intra-abdominal pressure transmission to the thorax is predominantly at end-inspiration [abstract].  American Journal of Respiratory and Critical Care Medicine. 2012
  • Tidal coefficient of variation as a predictor of weaning success [abstract].  American Journal of Respiratory and Critical Care Medicine. 2012