selected publications
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Journal Article
- A more gradual positive end-expiratory pressure increase reduces lung damage and improves cardiac function in experimental acute respiratory distress syndrome. Journal of applied physiology (Bethesda, Md.. 2022
- Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia. Intensive Care Medicine. 2022
- Reliable estimates of power delivery during mechanical ventilation utilizing easily obtained bedside parameters. Respiratory Care. 2022
- Dorsal push and abdominal binding improve respiratory compliance and driving pressure in proned coronavirus disease 2019 acute respiratory distress syndrome. Critical care explorations. 2021
- Elastic power of mechanical ventilation in morbid obesity and severe hypoxemia. Respiratory Care. 2021
- Intra-cycle power: is the flow profile a neglected component of lung protection?. Intensive Care Medicine. 2021
- Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury. Intensive care medicine experimental. 2021
- Paradoxically improved respiratory compliance with abdominal compression in COVID-19 ARDS. Chest. 2021
- Prevalence and outcome of silent hypoxemia in COVID-19. Minerva Anestesiologica. 2021
- Role of total lung stress on the progression of early COVID-19 pneumonia. Intensive Care Medicine. 2021
- The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome. Respiratory Research. 2021
- "Less is More" in mechanical ventilation. Intensive Care Medicine. 2020
- Does iso-mechanical power lead to iso-lung damage: an experimental study in a porcine model. Anesthesiology. 2020
- Elastic power but not driving power is the key promoter of ventilator-induced lung injury in experimental acute respiratory distress syndrome. Critical Care (London, England). 2020
- Estimating the damaging power of high-stress ventilation. Respiratory Care. 2020
- Management of COVID-19 respiratory distress. JAMA. 2020
- Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study. Intensive Care Medicine. 2020
- Time course of evolving ventilator-induced lung injury: the "shrinking baby lung". Critical Care Medicine. 2020
- What have we learned from animal models of ventilator-induced lung injury?. Intensive Care Medicine. 2020
- Driving pressure: defining the range. Respiratory Care. 2019
- Gradually increasing tidal volume may mitigate experimental lung injury in rats. Anesthesiology. 2019
- Positive end-expiratory pressure and mechanical power. Anesthesiology. 2019
- Understanding lactatemia in human sepsis. Potential impact for early management. American Journal of Respiratory and Critical Care Medicine. 2019
- Conditional hemodynamic tolerance to decremental recruitment of the "open lung". Critical Care Medicine. 2018
- Energetics and the root mechanical cause for ventilator-induced lung injury. Anesthesiology. 2018
- PEEP titration: the effect of prone position and abdominal pressure in an ARDS model. Intensive care medicine experimental. 2018
- Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis. Intensive care medicine experimental. 2018
- Protecting the ventilated lung: vascular surge and deflation energetics. American Journal of Respiratory and Critical Care Medicine. 2018
- Evidence or belief-based medicine? Ten doubts. Intensive Care Medicine. 2017
- Reliability of transpulmonary pressure-time curve profile to identify tidal recruitment/hyperinflation in experimental unilateral pleural effusion. Journal of Clinical Monitoring and Computing. 2017
- Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Medicine. 2017
- Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Critical Care Medicine. 2017
- Fast versus slow recruitment maneuver at different degrees of acute lung inflammation induced by experimental sepsis. Anesthesia and Analgesia. 2016
- Strain rate and cycling frequency-The "dynamic duo" of injurious tidal stress. Critical Care Medicine. 2016
- The effect of compartmental asymmetry on the monitoring of pulmonary mechanics and lung volumes. Respiratory Care. 2016
- Biological impact of transpulmonary driving pressure in experimental acute respiratory distress syndrome. Anesthesiology. 2015
- Critical care evidence--new directions. JAMA. 2015
- Diaphragm ultrasound as indicator of respiratory effort in critically ill patients undergoing assisted mechanical ventilation: a pilot clinical study. Critical Care (London, England). 2015
- Impact of chest wall modifications and lung injury on the correspondence between airway and transpulmonary driving pressures. Critical Care Medicine. 2015
- The top attributes of excellence of intensive care physicians. Intensive Care Medicine. 2015
- Development of a lethal, closed-abdomen, arterial hemorrhage model in noncoagulopathic swine. Journal of Surgical Research. 2014
- Drainage of pleural effusion in mechanically ventilated patients: time to measure chest wall compliance?. Journal of Critical Care. 2014
- Positional effects on lung volumes and transpulmonary pressure during unilateral mechanical asymmetry. Minnesota Medicine. 2014
- Self-expanding foam for prehospital treatment of intra-abdominal hemorrhage: 28-day survival and safety. The journal of trauma and acute care surgery. 2014
- Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study. The journal of trauma and acute care surgery. 2014
- Self-expanding foam improves survival following a lethal, exsanguinating iliac artery injury. The journal of trauma and acute care surgery. 2014
- Unilateral mechanical asymmetry. Positional effects on lung volumes and transpulmonary pressure. Intensive care medicine experimental. 2014
- Experimental intra-abdominal hypertension influences airway pressure limits for lung protective mechanical ventilation. The journal of trauma and acute care surgery. 2013
- Recruitment maneuvers modulate epithelial and endothelial cell response according to acute lung injury etiology. Critical Care Medicine. 2013
- Under pressure. Annals of the American Thoracic Society. 2013
- Value and limitations of transpulmonary pressure calculations during intra-abdominal hypertension. Critical Care Medicine. 2013
- Ventilator-associated problems related to obstructive lung disease. Respiratory Care. 2013
- Experimental intra-abdominal hypertension attenuates the benefit of positive end-expiratory pressure in ventilating effusion-compressed lungs*. Critical Care Medicine. 2012
- Dynamic hyperinflation and auto-positive end-expiratory pressure: lessons learned over 30 years. American Journal of Respiratory and Critical Care Medicine. 2011
- Impact of pressure profile and duration of recruitment maneuvers on morphofunctional and biochemical variables in experimental lung injury. Critical Care Medicine. 2011
- Non-pulmonary factors strongly influence the stress index. Intensive Care Medicine. 2011
- Pleural effusion complicates monitoring of respiratory mechanics. Critical Care Medicine. 2011
- Point: Is pressure assist-control preferred over volume assist-control mode for lung protective ventilation in patients with ARDS? Yes. Chest. 2011
- Recruitment by sustained inflation: time for a change. Intensive Care Medicine. 2011
- Spontaneously regulated vs. controlled ventilation of acute lung injury/acute respiratory distress syndrome. Current Opinion in Critical Care. 2011
- Agreement between functional residual capacity estimated via automated gas dilution versus via computed tomography in a pleural effusion model. Respiratory Care. 2010
- Can we prevent the spread of focal lung inflammation?. Critical Care Medicine. 2010
- Cardiovascular and metabolic effects of high-dose insulin in a porcine septic shock model. Academic Emergency Medicine. 2010
- Prone positioning for ARDS: defining the target. Intensive Care Medicine. 2010
- Safer ventilation of the injured lung: one step closer. Critical Care (London, England). 2010
- Thermal therapeutics: the importance of good timing. Anesthesia and Analgesia. 2010
- Thirty years of critical care medicine. Critical Care (London, England). 2010
- Acoustic monitoring--super sonics?. Critical Care (London, England). 2009
- Acute coronary thrombosis in a patient with septic shock without any evidence of disseminated intravascular coagulation. BMJ Case Reports. 2009
- Airway pressure release ventilation. Journal of burn care & research. 2009
- High dose insulin in toxic cardiogenic shock. Clinical Toxicology (Philadelphia, Pa.). 2009
- Semi-quantitative tracking of intra-airway fluids by computed tomography. Clinical Physiology and Functional Imaging. 2009
- Cigarettes-induced acute eosinophilic pneumonia: a case report 2008
- Do airway secretions play an underappreciated role in acute respiratory distress syndrome?. Current Opinion in Critical Care. 2008
- How best to recruit the injured lung?. Critical Care (London, England). 2008
- Lung injury--settle for a sketch or design a blueprint?. Critical Care Medicine. 2008
- Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 2008
- Meta-analysis: convenient assumptions and inconvenient truth. Critical Care Medicine. 2008
- Propagation prevention: a complementary mechanism for "lung protective" ventilation in acute respiratory distress syndrome. Critical Care Medicine. 2008
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Critical Care Medicine. 2008
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Medicine. 2008
- The pulmonary artery catheter: in medio virtus. Critical Care Medicine. 2008
- Ventilation patterns influence airway secretion movement. Respiratory Care. 2008
- The "open lung" compromise. Intensive Care Medicine. 2007
- Time course of physiologic variables in response to ventilator-induced lung injury. Respiratory Care. 2007
- A proposed curvilinearity index for quantifying airflow obstruction. Respiratory Care. 2006
- Limitations of clinical trials in acute lung injury and acute respiratory distress syndrome. Current Opinion in Critical Care. 2006
- Advances in the understanding of acute respiratory distress syndrome: summarizing a decade of progress. Current Opinion in Critical Care. 2004
- Effects of ventilatory pattern on experimental lung injury caused by high airway pressure. Critical Care Medicine. 2004
- Intercomparison of recruitment maneuver efficacy in three models of acute lung injury. Critical Care Medicine. 2004
- Partitioning the work-sparing effects of partial ventilatory support in airflow obstruction. Critical Care (London, England). 2004
- Reluctant horses at the digital river. Critical Care (London, England). 2004
- Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injury. Critical Care Medicine. 2004
- Ventilatory management of acute respiratory distress syndrome: a consensus of two. Critical Care Medicine. 2004
- Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injury. Critical Care (London, England). 2003
- Distal projection of insufflated gas during tracheal gas insufflation. Journal of applied physiology (Bethesda, Md.. 2002
- Oscillations and noise: inherent instability of pressure support ventilation?. American Journal of Respiratory and Critical Care Medicine. 2002
- Pulmonary microvascular fracture in a patient with acute respiratory distress syndrome. Critical Care Medicine. 2002
- Tracheal gas insufflation during late exhalation efficiently reduces PaCO(2) in experimental acute lung injury. Intensive Care Medicine. 2002
- Ventilation of patients with asthma and chronic obstructive pulmonary disease. Current Opinion in Critical Care. 2002
- Dynamic behavior during noninvasive ventilation: chaotic support?. American Journal of Respiratory and Critical Care Medicine. 2001
- Relative roles of vascular and airspace pressures in ventilator-induced lung injury. Critical Care Medicine. 2001
- Static and dynamic pressure-volume curves reflect different aspects of respiratory system mechanics in experimental acute respiratory distress syndrome. Respiratory Care. 2001
- Prone positioning attenuates and redistributes ventilator-induced lung injury in dogs. Critical Care Medicine. 2000
- Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange. American Journal of Respiratory and Critical Care Medicine. 2000
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Editorial Article
- "Established" respiratory treatment in acute respiratory distress syndrome: scientific rigor or a square peg in a round hole [editorial]?. American Journal of Respiratory and Critical Care Medicine. 203. 2021
- COVID-19 and ARDS: the baby lung size matters [editorial]. Intensive Care Medicine. 47. 2021
- Complexity and unanswered questions in the pathophysiology of COVID-19 ARDS [editorial]. Intensive Care Medicine. 47. 2021
- Conceptual simplicity in pursuit of precision [editorial]. Intensive Care Medicine. 47. 2021
- Isn't it time to abandon ARDS? The COVID-19 lesson [editorial]. Critical Care (London, England). 25. 2021
- Pathophysiology of COVID-19-associated acute respiratory distress syndrome [editorial]. The Lancet. Respiratory medicine. 9. 2021
- Reply to Tobin: Respiratory drive measurements do not signify conjectural patient self-inflicted lung injury [editorial]. American Journal of Respiratory and Critical Care Medicine. 203. 2021
- Smoothing the edges of lung protection [editorial]. American Journal of Respiratory and Critical Care Medicine. 203. 2021
- The 4DPRR Index and mechanical power: a step ahead or four steps backward [editorial]?. American Journal of Respiratory and Critical Care Medicine. 204. 2021
- COVID-19 phenotypes: leading or misleading [editorial]?. European Respiratory Journal. 56. 2020
- COVID-19: scientific reasoning, pragmatism and emotional bias [editorial]. Annals of intensive care. 10. 2020
- Dealing with the CARDS of COVID-19 [editorial]. Critical Care Medicine. 48. 2020
- Finding best PEEP: a little at a time [editorial]. Respiratory Care. 65. 2020
- Hysteresis as an indicator of recruitment and ventilator-induced lung injury risk [editorial]. Critical Care Medicine. 48. 2020
- Integrating the evidence: confronting the COVID-19 elephant [editorial]. Intensive Care Medicine. 46. 2020
- Recruiting the acutely injured lung: how and why [editorial]?. American Journal of Respiratory and Critical Care Medicine. 201. 2020
- Spontaneous breathing, transpulmonary pressure and mathematical trickery [editorial]. Annals of intensive care. 10. 2020
- The baby lung and the COVID-19 era [editorial]. Intensive Care Medicine. 46. 2020
- The respiratory drive: an overlooked tile of COVID-19 pathophysiology [editorial]. American Journal of Respiratory and Critical Care Medicine. 202. 2020
- Which component of mechanical power is most important in causing VILI [editorial]?. Critical Care (London, England). 24. 2020
- The tidal volume fix [editorial]?. Journal of Thoracic Disease. 11. 2019
- Conditional value of raising positive end-expiratory pressure to counter vigorous breathing efforts in injured lungs [editorial]. American Journal of Respiratory and Critical Care Medicine. 197. 2018
- Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No [editorial]. Intensive Care Medicine. 44. 2018
- Firmer footing for ventilating and monitoring the injured lung [editorial]. Journal of Thoracic Disease. 10. 2018
- Should we titrate positive end-expiratory pressure based on an end-expiratory transpulmonary pressure [editorial]?. Annals of translational medicine. 6. 2018
- Time to rethink the approach to treating acute respiratory distress syndrome [editorial]. JAMA. 319. 2018
- Volutrauma and atelectrauma: which is worse [editorial]?. Critical Care (London, England). 22. 2018
- Clinical deployment of the esophageal balloon catheter-making the case [editorial]. Critical Care Medicine. 45. 2017
- Transpulmonary pressure meaning: Babel or conceptual evolution [editorial]?. American Journal of Respiratory and Critical Care Medicine. 195. 2017
- Dynamic predictors of VILI risk: beyond the driving pressure [editorial]. Intensive Care Medicine. 42. 2016
- Should we embrace the "open lung" approach [editorial]?. Critical Care Medicine. 44. 2016
- Does high-pressure, high-frequency oscillation shake the foundations of lung protection [editorial]?. Intensive Care Medicine. 41. 2015
- Prone positioning and neuromuscular blocking agents are part of standard care in severe ARDS patients: we are not sure [editorial]. Intensive Care Medicine. 41. 2015
- Introduction (foreword) to the issue. Heart and lung monitoring [editorial]. Current Opinion in Critical Care. 20. 2014
- Mid-frequency ventilation: a viable option for lung protection [editorial]?. Respiratory Care. 59. 2014
- Spontaneous breathing, extrapulmonary CO(2) removal, and ventilator-induced lung injury risk: less power to the people [editorial]?. Critical Care Medicine. 42. 2014
- Lower tidal volumes for everyone: principle or prescription [editorial]?. Intensive Care Medicine. 39. 2013
- Monitoring breathing effort: a work in progress [editorial]. Critical Care Medicine. 41. 2013
- Position, positive end-expiratory pressure, and obstructive obesity [editorial]. Critical Care Medicine. 41. 2013
- Too much for too long-wrong targets, wrong timing [editorial]?. Critical Care Medicine. 41. 2013
- Transpulmonary pressure as a surrogate of plateau pressure for lung protective strategy: not perfect but more physiologic [editorial]. Intensive Care Medicine. 38. 2012
- Does positive end-expiratory pressure improve CO(2) exchange in controlled ventilation of acute airflow obstruction [editorial]?. Critical Care Medicine. 39. 2011
- Risk factors associated with early reintubation in trauma patients: a prospective observational study [invited editorial]. Journal of Trauma. 71. 2011
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Chapter
- Ventilatory management of obstructive airway disease. Critical care medicine: principles of diagnosis and management in the adult. 2014
- Position and the compromised respiratory system. Annual update in intensive care and emergency medicine. 2012
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Conference Poster
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Review
- COVID-19 pneumonia: pathophysiology and management [review]. European Respiratory Review: An Official Journal of the European Respiratory Society. 2021
- Improving lung compliance by external compression of the chest wall [review]. Critical Care (London, England). 2021
- Personalized mechanical ventilation in acute respiratory distress syndrome [review]. Critical Care (London, England). 2021
- Extracorporeal membrane oxygenation for respiratory failure [review]. Anesthesiology. 2020
- Prone position in ARDS patients: why, when, how and for whom [review]. Intensive Care Medicine. 2020
- Static and dynamic contributors to ventilator-induced lung injury in clinical practice. Pressure, energy, and power [review]. American Journal of Respiratory and Critical Care Medicine. 2020
- Acute lobar atelectasis [review]. Chest. 2019
- Evolving concepts for safer ventilation [review]. Critical Care (London, England). 2019
- Dissipation of energy during the respiratory cycle: conditional importance of ergotrauma to structural lung damage [review]. Current Opinion in Critical Care. 2018
- Physiology-guided management of hemodynamics in acute respiratory distress syndrome [review]. Annals of translational medicine. 2018
- Management of critical burn injuries: recent developments [review] 2017
- Respiratory support in patients with acute respiratory distress syndrome: an expert opinion [review]. Critical Care (London, England). 2017
- Seven unconfirmed ideas to improve future ICU practice [review]. Critical Care (London, England). 2017
- The future of mechanical ventilation: lessons from the present and the past [review]. Critical Care (London, England). 2017
- The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation [review]. Intensive Care Medicine. 2017
- Time-sensitive therapeutics [review]. Critical Care (London, England). 2017
- Excellence in intensive care medicine [review]. Critical Care Medicine. 2016
- Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation [review]. Intensive Care Medicine. 2016
- Is automated weaning superior to manual spontaneous breathing trials [review]?. Respiratory Care. 2016
- Should early prone positioning be a standard of care in ARDS with refractory hypoxemia [review]?. Respiratory Care. 2016
- The "baby lung" became an adult [review]. Intensive Care Medicine. 2016
- Lung recruitment in acute respiratory distress syndrome: what is the best strategy [review]?. Current Opinion in Critical Care. 2014
- Mechanical ventilation: past lessons and the near future [review]. Critical Care (London, England). 2013
- Our favorite unproven ideas for future critical care [review]. Critical Care (London, England). 2013
- Prone position in acute respiratory distress syndrome. Rationale, indications, and limits [review]. American Journal of Respiratory and Critical Care Medicine. 2013
- Two steps forward in bedside monitoring of lung mechanics: transpulmonary pressure and lung volume [review]. Critical Care (London, England). 2013
- Unproven clinical evidence in mechanical ventilation [review]. Current Opinion in Critical Care. 2012
- Update: adjuncts to mechanical ventilation [review]. Current Opinion in Anaesthesiology. 2012
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Abstract
- How does IAP affect esophageal pressure [abstract]?. American Journal of Respiratory and Critical Care Medicine. 2013
- Fowler's position reduces effusion-caused compressive lung stress and increases functional residual capacity [abstract]. American Journal of Respiratory and Critical Care Medicine. 2012
- Intra-abdominal pressure transmission to the thorax is predominantly at end-inspiration [abstract]. American Journal of Respiratory and Critical Care Medicine. 2012
- Tidal coefficient of variation as a predictor of weaning success [abstract]. American Journal of Respiratory and Critical Care Medicine. 2012