Value and limitations of transpulmonary pressure calculations during intra-abdominal hypertension Journal Article uri icon
  • OBJECTIVE: To clarify the effect of progressively increasing intra-abdominal pressure on esophageal pressure, transpulmonary pressure, and functional residual capacity. DESIGN: Controlled application of increased intra-abdominal pressure at two positive end-expiratory pressure levels (1 and 10 cm H2O) in an anesthetized porcine model of controlled ventilation. SETTING: Large animal laboratory of a university-affiliated hospital. SUBJECTS: Eleven deeply anesthetized swine (weight 46.2 +/- 6.2 kg). INTERVENTIONS: Air-regulated intra-abdominal hypertension (0-25 mm Hg). MEASUREMENTS: Esophageal pressure, tidal compliance, bladder pressure, and end-expiratory lung aeration by gas dilution. MAIN RESULTS: Functional residual capacity was significantly reduced by increasing intra-abdominal pressure at both positive end-expiratory pressure levels (p

  • Link to Article
    publication date
  • 2013
  • published in
  • Animal Studies
  • Critical Care
  • Lung
  • Respiration, Artificial
  • Additional Document Info
  • 41
  • issue
  • 8