Sotirios A. Parashos, MD, PhD
Medical Research Lead, Struthers Parkinson’s Center
About

HealthPartners/Park Nicollet Medical Group title: Associate Consultant, neurology

Academic appointment: Adjunct Professor of Neurology, University of Minnesota, Minneapolis

Education and training: MD, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; residency (neurology), University of Minnesota, Minneapolis; PhD (neurophysiology), School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; Fogarty Fellow, Experimental Therapeutics Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD; research fellow, Lab of Neurophysiology, Aristotle’s University of Thessaloniki, Thessaloniki, Greece; advanced clinical fellow (movement disorders), Division of Movement Disorders, Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

Overview/research interests: Sotirios A. Parashos, MD, PhD, is medical research lead at the Struthers Parkinson’s Center (Methodist Hospital), a Parkinson’s Foundation Center of Excellence. Dr. Parashos’ research in Parkinson’s disease focuses on non-dopa-responsive symptoms such as falls and cognitive dysfunction, the natural progression of Parkinson’s disease and the role of the multidisciplinary and interdisciplinary care in the management of Parkinson’s disease. He has co-authored many articles published in peer-reviewed journals, a book on Navigating Life with Parkinson’s Disease (part of the American Academy of Neurology’s Neurology Now series) and has given numerous lectures on Parkinson’s disease to professional and lay audiences. Dr. Parashos serves on the Community Advisory Board of the Struthers Parkinson’s Center, on the Work Group for Parkinson’s Disease Physician Performance Measure Development of the Quality Standards Subcommittee of the American Academy of Neurology and on the Quality Improvement Initiative of the Parkinson’s Foundation.

Current research activities and funding:

  • Role of attention in gait and balance in Parkinson’s disease; Funder: SPC; Role: Co-PI
  • A Phase 3, 12-week, Multicenter, Multinational, Randomized, Double-Blind, Double-Dummy, Parallel Group Study to Determine the Efficacy, Safety and Tolerability of P2B001 Once Daily Compared to its Individual Components in Subjects with Early Parkinson’s Disease and to a Calibration Arm of Pramipexole ER; Funder: Pharma2B; Role; Site PI
  • A Phase 3, four-week, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure; Funder: Theravance Biopharma; Role: Site PI
  • A Randomized Controlled Study to Compare the Safety and Efficacy of IPX203 with Immediate-Release Carbidopa-Levodopa in Parkinson’s Disease Patients with Motor Fluctuations; Funder: IMMPAX Laboratories; Role: Site PI
  • Evaluation of Oral Anti-Parkinsonian Medication Use in Patients with Advanced Parkinson’s Disease with History of Deep Brain Stimulation (DBS) and Being Treated with Carbidopa Levodopa Enteral Suspension (CLES); Funder: Abbvie; Role: Site PI
  • National Parkinson’s Foundation Patient Registry; Funder: NPF; Role: site PI
  • Milestones of Disease Progression and Disability in Parkinson’s Disease: A Hypothesis and First Testing; Funder: SPC; Role: site PI
  • Risk and Protective Factors for Falls in Parkinson’s Disease; Funder: NPF; Role: Co-investigator
Affiliation
positions
  • Research Investigator, Neuroscience Research Centers
  • Publications While At HealthPartners
    Highlights
    selected publications
    Journal Article
  • Falls and injuries resulting from falls among patients with parkinsonism: a reappraisal. 
    Movement disorders clinical practice. 2026
  • The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson's disease. 
    Nat Aging. 2026
  • The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies. 
    Alzheimer's & dementia (Amsterdam, Netherlands). 2024
  • Validation of the Rainbow Model of Integrated Care Measurement Tool in Parkinson's disease. 
    Movement Disorders. 2023
  • Hip fracture care in Parkinson disease: a retrospective analysis of 1,239 patients. 
    Geriatric orthopaedic surgery & rehabilitation. 2022
  • A retrospective study evaluating the use of anti-Parkinsonian medications in patients with advanced Parkinson’s disease who are treated with Levodopa-Carbidopa Intestinal Gel and deep brain stimulation: the PD-DUAL Study. 
    Neurology. 2021
  • Longitudinal change in quality of life in neurological disorders measures over 3 years in patients with early Parkinson's disease. 
    Movement Disorders. 2021
  • Recommendations for the organization of multidisciplinary clinical care teams in Parkinson's disease. 
    Journal of Parkinson's Disease. 2020
  • Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial. 
    Neurology. 2019
  • Pooled analyses of phase III studies of ADS-5102 (Amantadine) extended-release capsules for dyskinesia in Parkinson's disease. 
    CNS drugs. 2018
  • What predicts falls in Parkinson disease? Observations from the Parkinson's Foundation registry. 
    Neurology. Clinical practice. 2018
  • Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort. 
    Journal of the Neurological Sciences. 2017
  • Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1. 
    Parkinsonism & Related Disorders. 2016
  • Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. 
    JAMA. 2015
  • Validation of an ambulatory capacity measure in Parkinson disease: a construct derived from the Unified Parkinson's Disease Rating Scale. 
    Journal of Parkinson's Disease. 2015
  • Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. 
    JAMA neurology. 2014
  • Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. 
    JAMA neurology. 2014
  • Mobility, mood and site of care impact health related quality of life in Parkinson's disease. 
    Parkinsonism & Related Disorders. 2014
  • Falls in Parkinson disease: analysis of a large cross-sectional cohort. 
    Journal of Parkinson's Disease. 2013
  • Sexual and relationship satisfaction among persons with young-onset Parkinson's disease. 
    Journal of Sexual Medicine. 2010
  • Determinants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience. 
    Archives of Neurology. 2009
  • Prominent phenotypic variability associated with mutations in Progranulin. 
    Neurobiology of Aging. 2009
  • Falls and injuries resulting from falls among patients with Parkinson's disease and other parkinsonian syndromes. 
    Movement Disorders. 2005
  • Frequency, reasons, and risk factors of entacapone discontinuation in Parkinson disease. 
    Clinical Neuropharmacology. 2004
  • Editorial Article
  • Recommendations for virtual administration of the PSP Rating Scale [editorial]. 
    Movement Disorders.  37. 2022
  • Attention training improves attention and gait in Parkinson disease: a pilot study [editorial]. 
    Parkinsonism & Related Disorders.  60. 2019
  • Parkinson's disease physiotherapy: specialisation adds value [editorial]. 
    Lancet Neurology.  17. 2018
  • Challenges of multidisciplinary care in Parkinson's disease [editorial]. 
    Lancet Neurology.  12. 2013
  • Review
  • Integrated care in Parkinson's disease: a systematic review and meta-analysis [meta-analysis, review, systematic review]. 
    Movement Disorders. 2020
  • Disability rating scales in Parkinson's disease: Critique and recommendations [review]. 
    Movement Disorders. 2016
  • Abstract
  • A retrospective study evaluating the use of anti-Parkinsonian medications in patients with advanced Parkinson's disease treated with Levodopa-Carbidopa Intestinal Gel and deep brain stimulation [abstract]. 
    Journal of the Neurological Sciences. 2021
  • Contact
    full name
  • Sotirios A. Parashos, MD, PhD
  • located in facility
    Quick Info
    Publications
    Publications in the past 10 years based solely on publications while at HealthPartners. Publications in prior years appear in grey.
    Collaboration
    More Info