Pawloski, Pamala A., PharmD, BCOP, FCCP
Senior Research Investigator

Positions

Senior Research Investigator, Cancer Research Center

Joined the Institute: 2008

Education and training: PharmD, North Dakota State University; pharmacy practice residency and oncology pharmacy practice residency, University of Kentucky; clinical pharmacology fellowship, University of Texas M.D. Anderson Cancer Center.

Overview/research interests: Optimizing patient outcomes by improving medication management through the application of pharmacogenomics, medication therapy management and medication surveillance.

Current research activities and funding:

Cancer Treatment and Supportive Care Outcomes

CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems (NCI)
Pilot Testing a Biorepository Framework to Enable Genomic Research at HP (HPI)
Treatment, Experiences and Barriers among Elderly Colorectal Cancer Patients (PCORI)
Implementing Universal Lynch Syndrome Screening across Multiple Healthcare Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts (NCI)

Medication Safety and Adverse Event Surveillance

Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) Maintenance (FDA)
Evaluation of the Risk of Neural Tube Defects Among Live Births Exposed to Maternal Prescription Opioids During Early Pregnancy (FDA)
FDA Sentinel Initiative (FDA)
Innovation in Medical Evidence and Development Surveillance (IMEDS) Signal Refinement and Signal Characterization Bundles (public-private
Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) Comparative Effectiveness of Biosimilars (public-private)

Publications

selected publications

Journal Article
- Characteristics of state legislation addressing prescription drug price increases in the United States, 2020. Journal of General Internal Medicine. 2022
- The association of bowel function, participation in life activities, and quality of life in rectal cancer survivors. Quality of Life Research. 2022
- Validation of diagnosis codes to identify hospitalized COVID-19 patients in health care claims data. Pharmacoepidemiology and Drug Safety. 2022
- A randomized trial of medical cannabis in patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient satisfaction. Supportive Care in Cancer. 2021
- Assessment of oral chemotherapy nonadherence in chronic myeloid leukemia patients using brief measures in community cancer clinics: a pilot study. International Journal of Environmental Research and Public Health. 2021
- Patient characteristics and utilization patterns of short-acting recombinant granulocyte colony-stimulating factor (G-CSF) biosimilars compared to their reference product. Drugs - real world outcomes. 2021
- Pharmacogenomics education, research and clinical implementation in the state of Minnesota. Pharmacogenomics. 2021
- Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014. Pharmacoepidemiology and Drug Safety. 2021
- A population-based survey to assess the association between cannabis and quality of life among colorectal cancer survivors. BMC cancer. 2020
- Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence. Breast Cancer Research and Treatment. 2020
- Cardiovascular events and costs with home blood pressure telemonitoring and pharmacist management for uncontrolled hypertension. Hypertension (Dallas, Tex.. 2020
- Characteristics and price increases among sole-source, off-patent drugs in the United States, 2008 to 2018. JAMA network open. 2020
- Design of a pragmatic cluster-randomized trial comparing telehealth care and best practice clinic-based care for uncontrolled high blood pressure. Contemporary Clinical Trials. 2020
- Developing a standardized and reusable method to link distributed health plan databases to the National Death Index: methods development study protocol. JMIR research protocols. 2020
- Validity of diagnosis and procedure codes for identifying neural tube defects in infants. Pharmacoepidemiology and Drug Safety. 2020
- Variation in colorectal cancer stage and mortality across large community-based populations: PORTAL Colorectal Cancer Cohort. The Permanente journal. 2020
- Clinical molecular marker testing data capture to promote precision medicine research within the Cancer Research Network. JCO clinical cancer informatics. 2019
- Descriptive analysis of long- and intermediate-acting insulin and key safety outcomes in adults with type 2 diabetes mellitus. Journal of managed care & specialty pharmacy. 2019
- Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to evaluate patterns of care. Journal of managed care & specialty pharmacy. 2019
- Health care improvement and survivorship priorities of colorectal cancer survivors: findings from the PORTAL colorectal cancer cohort survey. Supportive Care in Cancer. 2019
- Health-related quality of life among US adults with cancer: potential roles of complementary and alternative medicine for health promotion and well-being. Psycho-Oncology. 2019
- Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018. PloS One. 2019
- Long-term patterns of oral anticancer agent adoption, duration, and switching in patients with CML. Journal of the National Comprehensive Cancer Network. 2019
- PCSK9 inhibitor use in the real world: data From the National Patient-Centered Research Network. Journal of the American Heart Association. 2019
- Predictors of long-term survival among high-grade serous ovarian cancer patients. Cancer Epidemiology, Biomarkers and Prevention. 2019
- Pregnancy-associated cancer: a U.S. population-based study 2019
- The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine. EGEMS (Washington, DC). 2019
- Treatment patterns and survival differ between early-onset and late-onset colorectal cancer patients: the patient outcomes to advance learning network. Cancer Causes and Control. 2019
- Unique case report of a meningeal sarcoma arising during ongoing treatment for progressing intraparenchymal glioma 2019
- Economic evaluation of the home blood pressure telemonitoring and pharmacist case management to control hypertension (Hyperlink) trial 2018
- Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts. BMC Health Services Research. 2018
- Key components of success in a randomized trial of blood pressure telemonitoring with medication therapy management pharmacists. Journal of the American Pharmacists Association. 2018
- Long-term outcomes of the effects of home blood pressure telemonitoring and pharmacist management on blood pressure among adults with uncontrolled hypertension: follow-up of a cluster randomized clinical trial. JAMA network open. 2018
- Navigating the complex landscape of genetic testing: genetics professionals are a key resource. MetroDoctors. 2018
- Opioid use during pregnancy, observations of opioid use, and secular trend from 2006 to 2014 at HealthPartners Medical Group. Clinical Journal of Pain. 2018
- Accuracy of electronic health record-derived data for the identification of incident ADHD 2017
- Establishment of personalized pain goals in oncology patients to improve care and decrease costs. Journal of Oncology Practice. 2017
- Optimizing patient-reported outcome and risk factor reporting from cancer survivors: a randomized trial of four different survey methods among colorectal cancer survivors. Journal of Cancer Survivorship. 2017
- Predicting neutropenia risk in patients with cancer using electronic data. Journal of the American Medical Informatics Association. 2017
- The financial toll of cancer therapy: developing ways to help the patient. Minn Physician. 2017
- Training in the conduct of population-based multi-site and multi-disciplinary studies: the Cancer Research Network's Scholars Program. Journal of Cancer Education. 2017
- A substudy evaluating treatment intensification on medication adherence among hypertensive patients receiving home blood pressure telemonitoring and pharmacist management. Journal of Clinical Pharmacy and Therapeutics. 2016
- Patient characteristics associated with greater blood pressure control in a randomized trial of home blood pressure telemonitoring and pharmacist management. Journal of the American Society of Hypertension. 2016
- Pegfilgrastim use and bone pain: a cohort study of community-based cancer patients. Journal of Oncology Pharmacy Practice. 2016
- Proton pump inhibitor use by aspirin-treated coronary artery disease patients is not associated with increased risk of cardiovascular events. European heart journal. Cardiovascular pharmacotherapy. 2016
- The Cancer Research Network: a platform for epidemiologic and health services research on cancer prevention, care, and outcomes in large, stable populations. Cancer Causes and Control. 2016
- Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies. Pharmacoepidemiology and Drug Safety. 2016
- A successful multifaceted trial to improve hypertension control in primary care: why did it work?. Journal of General Internal Medicine. 2015
- Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases. Pharmacoepidemiology and Drug Safety. 2015
- Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiology and Drug Safety. 2014
- Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer. Breast Cancer Research and Treatment. 2014
- Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample. PloS One. 2014
- Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study. Breast Cancer Research and Treatment. 2014
- Pharmacotherapy for incident attention-deficit/hyperactivity disorder: practice patterns and quality metrics. Current Medical Research and Opinion. 2014
- Phase II study of biweekly carboplatin, gemcitabine, and bevacizumab as first-line treatment in patients with stage IIIB/IV NSCLC. American Journal of Clinical Oncology. 2014
- The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007. Maternal and child health journal. 2014
- Trends in elective labor induction for six United States health plans, 2001-2007 2014
- Barriers to and facilitators of medication adherence. American Journal of Pharmacy Benefits. 2013
- Chronic use of opioid medications before and after bariatric surgery. JAMA. 2013
- Drug adverse event detection in health plan data using the gamma poisson shrinker and comparison to the tree-based scan statistic. Pharmaceutics. 2013
- Drug safety data mining with a tree-based scan statistic. Pharmacoepidemiology and Drug Safety. 2013
- Fracture risk in older, long-term survivors of early-stage breast cancer. Journal of the American Geriatrics Society. 2013
- Incident malignancies among older long-term breast cancer survivors and an age-matched and site-matched nonbreast cancer comparison group over 10 years of follow-up. Cancer. 2013
- KRAS testing and epidermal growth factor receptor inhibitor treatment for colorectal cancer in community settings. Cancer Epidemiology, Biomarkers and Prevention. 2013
- Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy. Maternal and child health journal. 2013
- Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes. Pharmacoepidemiology and Drug Safety. 2013
- Oncologists' attitudes toward KRAS testing: a multisite study. Cancer medicine. 2013
- Patient characteristics associated with medication adherence. Clinical Medicine & Research. 2013
- Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries 2013
- Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007. Obstetrics and Gynecology. 2013
- Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer. Genetics in Medicine. 2013
- Validation of an algorithm to estimate gestational age in electronic health plan databases. Pharmacoepidemiology and Drug Safety. 2013
- Validation of anaphylaxis in the Food and Drug Administration's Mini-Sentinel. Pharmacoepidemiology and Drug Safety. 2013
- Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database. Pharmacoepidemiology and Drug Safety. 2013
- Validity of health plan and birth certificate data for pregnancy research. Pharmacoepidemiology and Drug Safety. 2013
- Development of clinical pharmacy productivity metrics. American Journal of Health-System Pharmacy. 2012
- Medication Exposure in Pregnancy Risk Evaluation Program. Maternal and child health journal. 2012
- The genome comes to the clinic: using pharmacogenetic data for treatment-related decisions. Minn Physician. 2012
- Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study. Paediatric and Perinatal Epidemiology. 2012
- ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. JAMA. 2011
- Age, comorbidity, and breast cancer severity: impact on receipt of definitive local therapy and rate of recurrence among older women with early-stage breast cancer. Journal of the American College of Surgeons. 2011
Editorial Article
- Cancer screening results and follow-up using routinely collected electronic health data: estimates for breast, colon, and cervical cancer screenings [editorial]. Journal of General Internal Medicine. 34. 2019
- How clinical pharmacists can improve outpatient diabetes care [editorial]. Diabetes Management (London, England). 4. 2014
- Personalized and prioritized diabetes treatment recommendations to reduce cardiovascular risk [editorial] 2014
Chapter
- Health maintenance organizations/health plans. Pharmacoepidemiology. 2012
Conference Paper
Conference Poster
Review
- A systematic review of clinical decision support systems for clinical oncology practice [systematic review]. Journal of the National Comprehensive Cancer Network. 2019
Abstract
- Diagnosis and treatment of neuropathy postchemotherapy in three health systems [abstract]. Journal of patient-centered research and reviews. 2019
- Long-term effects on cardiovascular events of home blood pressure telemonitoring with pharmacist management in patients with uncontrolled hypertension [abstract]. Journal of patient-centered research and reviews. 2019
- Tumor characteristics and treatment in early-onset colorectal cancer [abstract]. Journal of Clinical Oncology. 2018
- Assessing the adoption and application of the 2013 ACC/AHA guidelines for statin prescribing [abstract]. Journal of Managed Care Pharmacy. 2017
- Opioid prescribing during pregnancy: eight-year secular trends at HealthPartners Medical Group [abstract]. Journal of patient-centered research and reviews. 2017
- Application of statin medication adherence trajectory models in an integrated financing and care delivery system [abstract]. Pharmacotherapy. 2016
- Clinical and demographic characteristics of patients receiving opioid therapy during pregnancy [abstract]. Pharmacotherapy. 2016
- Qualitative data from a trial of home blood pressure telemonitoring and pharmacist management (Hyperlink) [abstract]. Journal of patient-centered research and reviews. 2016
- Retrospective analysis of a multidisciplinary antihypertensive protocol [abstract]. Journal of Managed Care Pharmacy. 2016
- Chemotherapy treatment patterns among advanced colon cancer patients [abstract]. Clinical Medicine & Research. 2012
- Evaluation of the validity of the gestational length assumptions based upon ddministrative health plan data [abstract]. Clinical Medicine & Research. 2012
- C-a4-03: Medication adherence in patients with uncontrolled blood pressure: results from the Hyperlink Study [abstract]. Clinical Medicine & Research. 2011
- Current use of KRAS testing in clinical practice [abstract]. Clinical Medicine & Research. 2011
- KRAS testing in metastatic colorectal cancer: the CERGEN-C comparative effectiveness study [abstract]. Clinical Medicine & Research. 2011
- PS1-18: A feasibility pilot to determine the practicality of using the HMO Research Network to research the genetics of drug-induced serious adverse events [abstract]. Clinical Medicine & Research. 2011
- PS1-31: Assessing the potential for research on genetics of drug induced liver injury in the HMORN [abstract]. Clinical Medicine & Research. 2011
- Participant characteristics associated with medication adherence [abstract]. Journal of Managed Care Pharmacy. 2011
- Patient characteristics associated with medication adherence [abstract]. Clinical Medicine & Research. 2011
- Validation of genomic markers that predict distant recurrence risk via FISH assays in women with early stage breast carcinoma [abstract]. Journal of Clinical Oncology. 2007

presentations