Pawloski, Pamala A., PharmD, BCOP, FCCP
Senior Research Investigator
About

Joined the Institute: 2008

Education and training: PharmD, North Dakota State University; pharmacy practice residency and oncology pharmacy practice residency, University of Kentucky; clinical pharmacology fellowship, University of Texas M.D. Anderson Cancer Center.

Overview/research interests: Optimizing patient outcomes by improving medication management through the application of pharmacogenomics, medication therapy management and medication surveillance.

Current research activities and funding:

Cancer Treatment and Supportive Care Outcomes

  • CRN4: Cancer Research Resources & Collaboration in Integrated Health Care Systems (NCI)
  • Pilot Testing a Biorepository Framework to Enable Genomic Research at HP (HPI)
  • Treatment, Experiences and Barriers among Elderly Colorectal Cancer Patients (PCORI)
  • Implementing Universal Lynch Syndrome Screening across Multiple Healthcare Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts (NCI)

Medication Safety and Adverse Event Surveillance

  • Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) Maintenance (FDA)
  • Evaluation of the Risk of Neural Tube Defects Among Live Births Exposed to Maternal Prescription Opioids During Early Pregnancy (FDA)
  • FDA Sentinel Initiative (FDA)
  • Innovation in Medical Evidence and Development Surveillance (IMEDS) Signal Refinement and Signal Characterization Bundles (public-private
  • Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) Comparative Effectiveness of Biosimilars (public-private)
Affiliation
positions
  • Senior Research Investigator, Cancer Research Center
  • Publications
    selected publications
    Journal Article
  • Association of COVID-19 vs influenza with risk of arterial and venous thrombotic events among hospitalized patients
    JAMA. 2022
  • Characteristics of state legislation addressing prescription drug price increases in the United States, 2020
    Journal of General Internal Medicine. 2022
  • Comparing pharmacist-led telehealth care and clinic-based care for uncontrolled high blood pressure: the Hyperlink 3 pragmatic cluster-randomized trial
    Hypertension (Dallas, Tex.. 2022
  • Comparison of explanatory and pragmatic design choices in a cluster-randomized hypertension trial: effects on enrollment, participant characteristics, and adherence
    Trials. 2022
  • Demographic differences in willingness to share electronic health records in the All of Us Research Program
    Journal of the American Medical Informatics Association. 2022
  • Developing an algorithm across integrated healthcare systems to identify a history of cancer using electronic medical records
    Journal of the American Medical Informatics Association. 2022
  • Patient characteristics, pain treatment patterns, and incidence of total joint replacement in a US population with osteoarthritis
    BMC Musculoskeletal Disorders. 2022
  • Should health systems share genetic findings with at-risk relatives when the proband is deceased? Interviews with individuals diagnosed with Lynch syndrome
    Journal of patient-centered research and reviews. 2022
  • The association of bowel function, participation in life activities, and quality of life in rectal cancer survivors
    Quality of Life Research. 2022
  • Validation of diagnosis codes to identify hospitalized COVID-19 patients in health care claims data
    Pharmacoepidemiology and Drug Safety. 2022
  • A randomized trial of medical cannabis in patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient satisfaction
    Supportive Care in Cancer. 2021
  • Assessment of oral chemotherapy nonadherence in chronic myeloid leukemia patients using brief measures in community cancer clinics: a pilot study
    International Journal of Environmental Research and Public Health. 2021
  • BBCIC Research Network analysis of first-cycle prophylactic G-CSF use in patients treated with high-neutropenia risk chemotherapy
    Journal of the National Comprehensive Cancer Network. 2021
  • Patient characteristics and utilization patterns of short-acting recombinant granulocyte colony-stimulating factor (G-CSF) biosimilars compared to their reference product
    Drugs - real world outcomes. 2021
  • Pharmacogenomics education, research and clinical implementation in the state of Minnesota
    Pharmacogenomics. 2021
  • Population characteristics, use, and spending on sole-source, off-patent drugs among commercial insurance members in the United States—an analysis of outpatient claims data at a single health plan
    Journal of the American College of Clinical Pharmacy. 2021
  • Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014
    Pharmacoepidemiology and Drug Safety. 2021
  • A population-based survey to assess the association between cannabis and quality of life among colorectal cancer survivors
    BMC cancer. 2020
  • Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence
    Breast Cancer Research and Treatment. 2020
  • Cardiovascular events and costs with home blood pressure telemonitoring and pharmacist management for uncontrolled hypertension
    Hypertension (Dallas, Tex.. 2020
  • Characteristics and price increases among sole-source, off-patent drugs in the United States, 2008 to 2018
    JAMA network open. 2020
  • Design of a pragmatic cluster-randomized trial comparing telehealth care and best practice clinic-based care for uncontrolled high blood pressure
    Contemporary Clinical Trials. 2020
  • Developing a standardized and reusable method to link distributed health plan databases to the National Death Index: methods development study protocol
    JMIR research protocols. 2020
  • Validity of diagnosis and procedure codes for identifying neural tube defects in infants
    Pharmacoepidemiology and Drug Safety. 2020
  • Variation in colorectal cancer stage and mortality across large community-based populations: PORTAL Colorectal Cancer Cohort
    The Permanente journal. 2020
  • Clinical molecular marker testing data capture to promote precision medicine research within the Cancer Research Network
    JCO clinical cancer informatics. 2019
  • Descriptive analysis of long- and intermediate-acting insulin and key safety outcomes in adults with type 2 diabetes mellitus
    Journal of managed care & specialty pharmacy. 2019
  • Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to evaluate patterns of care
    Journal of managed care & specialty pharmacy. 2019
  • Health care improvement and survivorship priorities of colorectal cancer survivors: findings from the PORTAL colorectal cancer cohort survey
    Supportive Care in Cancer. 2019
  • Health-related quality of life among US adults with cancer: potential roles of complementary and alternative medicine for health promotion and well-being
    Psycho-Oncology. 2019
  • Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018
    PloS One. 2019
  • Long-term patterns of oral anticancer agent adoption, duration, and switching in patients with CML
    Journal of the National Comprehensive Cancer Network. 2019
  • PCSK9 inhibitor use in the real world: data From the National Patient-Centered Research Network
    Journal of the American Heart Association. 2019
  • Predictors of long-term survival among high-grade serous ovarian cancer patients
    Cancer Epidemiology, Biomarkers and Prevention. 2019
  • Pregnancy-associated cancer: a U.S. population-based study
    2019
  • The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine
    EGEMS (Washington, DC). 2019
  • Treatment patterns and survival differ between early-onset and late-onset colorectal cancer patients: the patient outcomes to advance learning network
    Cancer Causes and Control. 2019
  • Unique case report of a meningeal sarcoma arising during ongoing treatment for progressing intraparenchymal glioma
    2019
  • Economic evaluation of the home blood pressure telemonitoring and pharmacist case management to control hypertension (Hyperlink) trial
    Journal of the American College of Clinical Pharmacy. 2018
  • Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts
    BMC Health Services Research. 2018
  • Key components of success in a randomized trial of blood pressure telemonitoring with medication therapy management pharmacists
    Journal of the American Pharmacists Association. 2018
  • Long-term outcomes of the effects of home blood pressure telemonitoring and pharmacist management on blood pressure among adults with uncontrolled hypertension: follow-up of a cluster randomized clinical trial
    JAMA network open. 2018
  • Navigating the complex landscape of genetic testing: genetics professionals are a key resource
    MetroDoctors. 2018
  • Opioid use during pregnancy, observations of opioid use, and secular trend from 2006 to 2014 at HealthPartners Medical Group
    Clinical Journal of Pain. 2018
  • Accuracy of electronic health record-derived data for the identification of incident ADHD
    2017
  • Establishment of personalized pain goals in oncology patients to improve care and decrease costs
    Journal of Oncology Practice. 2017
  • Optimizing patient-reported outcome and risk factor reporting from cancer survivors: a randomized trial of four different survey methods among colorectal cancer survivors
    Journal of Cancer Survivorship. 2017
  • Predicting neutropenia risk in patients with cancer using electronic data
    Journal of the American Medical Informatics Association. 2017
  • The financial toll of cancer therapy: developing ways to help the patient
    Minn Physician. 2017
  • Training in the conduct of population-based multi-site and multi-disciplinary studies: the Cancer Research Network's Scholars Program
    Journal of Cancer Education. 2017
  • A substudy evaluating treatment intensification on medication adherence among hypertensive patients receiving home blood pressure telemonitoring and pharmacist management
    Journal of Clinical Pharmacy and Therapeutics. 2016
  • Patient characteristics associated with greater blood pressure control in a randomized trial of home blood pressure telemonitoring and pharmacist management
    Journal of the American Society of Hypertension. 2016
  • Pegfilgrastim use and bone pain: a cohort study of community-based cancer patients
    Journal of Oncology Pharmacy Practice. 2016
  • Proton pump inhibitor use by aspirin-treated coronary artery disease patients is not associated with increased risk of cardiovascular events
    European heart journal. Cardiovascular pharmacotherapy. 2016
  • The Cancer Research Network: a platform for epidemiologic and health services research on cancer prevention, care, and outcomes in large, stable populations
    Cancer Causes and Control. 2016
  • Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies
    Pharmacoepidemiology and Drug Safety. 2016
  • A successful multifaceted trial to improve hypertension control in primary care: why did it work?
    Journal of General Internal Medicine. 2015
  • Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases
    Pharmacoepidemiology and Drug Safety. 2015
  • Chronic opioid use emerging after bariatric surgery
    Pharmacoepidemiology and Drug Safety. 2014
  • Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer
    Breast Cancer Research and Treatment. 2014
  • Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample
    PloS One. 2014
  • Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study
    Breast Cancer Research and Treatment. 2014
  • Pharmacotherapy for incident attention-deficit/hyperactivity disorder: practice patterns and quality metrics
    Current Medical Research and Opinion. 2014
  • Phase II study of biweekly carboplatin, gemcitabine, and bevacizumab as first-line treatment in patients with stage IIIB/IV NSCLC
    American Journal of Clinical Oncology. 2014
  • The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007
    Maternal and child health journal. 2014
  • Trends in elective labor induction for six United States health plans, 2001-2007
    2014
  • Barriers to and facilitators of medication adherence
    American Journal of Pharmacy Benefits. 2013
  • Chronic use of opioid medications before and after bariatric surgery
    JAMA. 2013
  • Drug adverse event detection in health plan data using the gamma poisson shrinker and comparison to the tree-based scan statistic
    Pharmaceutics. 2013
  • Drug safety data mining with a tree-based scan statistic
    Pharmacoepidemiology and Drug Safety. 2013
  • Fracture risk in older, long-term survivors of early-stage breast cancer
    Journal of the American Geriatrics Society. 2013
  • Incident malignancies among older long-term breast cancer survivors and an age-matched and site-matched nonbreast cancer comparison group over 10 years of follow-up
    Cancer. 2013
  • KRAS testing and epidermal growth factor receptor inhibitor treatment for colorectal cancer in community settings
    Cancer Epidemiology, Biomarkers and Prevention. 2013
  • Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy
    Maternal and child health journal. 2013
  • Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes
    Pharmacoepidemiology and Drug Safety. 2013
  • Oncologists' attitudes toward KRAS testing: a multisite study
    Cancer medicine. 2013
  • Patient characteristics associated with medication adherence
    Clinical Medicine & Research. 2013
  • Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries
    2013
  • Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007
    Obstetrics and Gynecology. 2013
  • Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer
    Genetics in Medicine. 2013
  • Validation of an algorithm to estimate gestational age in electronic health plan databases
    Pharmacoepidemiology and Drug Safety. 2013
  • Validation of anaphylaxis in the Food and Drug Administration's Mini-Sentinel
    Pharmacoepidemiology and Drug Safety. 2013
  • Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database
    Pharmacoepidemiology and Drug Safety. 2013
  • Validity of health plan and birth certificate data for pregnancy research
    Pharmacoepidemiology and Drug Safety. 2013
  • Development of clinical pharmacy productivity metrics
    American Journal of Health-System Pharmacy. 2012
  • Medication Exposure in Pregnancy Risk Evaluation Program
    Maternal and child health journal. 2012
  • The genome comes to the clinic: using pharmacogenetic data for treatment-related decisions
    Minn Physician. 2012
  • Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study
    Paediatric and Perinatal Epidemiology. 2012
  • ADHD medications and risk of serious cardiovascular events in young and middle-aged adults
    JAMA. 2011
  • Age, comorbidity, and breast cancer severity: impact on receipt of definitive local therapy and rate of recurrence among older women with early-stage breast cancer
    Journal of the American College of Surgeons. 2011
  • Chapter
  • Health maintenance organizations/health plans
    Pharmacoepidemiology. 2012
  • Abstract
  • Beyond implementation: developing and utilizing a 5-factor scale to measure optimization of Lynch syndrome tumor screening programs in health systems [abstract]
    Journal of patient-centered research and reviews. 2021
  • Comparing change in systolic blood pressure with clinic-based care versus telehealth care in a pragmatic cluster-randomized trial (Hyperlink 3) [abstract]
    Journal of patient-centered research and reviews. 2021
  • Medication adherence during the COVID-19 pandemic: preliminary data from the patient perspective [abstract]
    Journal of patient-centered research and reviews. 2021
  • Diagnosis and treatment of neuropathy postchemotherapy in three health systems [abstract]
    Journal of patient-centered research and reviews. 2019
  • Long-term effects on cardiovascular events of home blood pressure telemonitoring with pharmacist management in patients with uncontrolled hypertension [abstract]
    Journal of patient-centered research and reviews. 2019
  • Tumor characteristics and treatment in early-onset colorectal cancer [abstract]
    Journal of Clinical Oncology. 2018
  • Assessing the adoption and application of the 2013 ACC/AHA guidelines for statin prescribing [abstract]
    Journal of Managed Care Pharmacy. 2017
  • Opioid prescribing during pregnancy: eight-year secular trends at HealthPartners Medical Group [abstract]
    Journal of patient-centered research and reviews. 2017
  • Application of statin medication adherence trajectory models in an integrated financing and care delivery system [abstract]
    Pharmacotherapy. 2016
  • Clinical and demographic characteristics of patients receiving opioid therapy during pregnancy [abstract]
    Pharmacotherapy. 2016
  • Qualitative data from a trial of home blood pressure telemonitoring and pharmacist management (Hyperlink) [abstract]
    Journal of patient-centered research and reviews. 2016
  • Retrospective analysis of a multidisciplinary antihypertensive protocol [abstract]
    Journal of Managed Care Pharmacy. 2016
  • Chemotherapy treatment patterns among advanced colon cancer patients [abstract]
    Clinical Medicine & Research. 2012
  • Evaluation of the validity of the gestational length assumptions based upon ddministrative health plan data [abstract]
    Clinical Medicine & Research. 2012
  • A feasibility pilot to determine the practicality of using the HMO Research Network to research the genetics of drug-induced serious adverse events [abstract]
    Clinical Medicine & Research. 2011
  • Current use of KRAS testing in clinical practice [abstract]
    Clinical Medicine & Research. 2011
  • KRAS testing in metastatic colorectal cancer: the CERGEN-C comparative effectiveness study [abstract]
    Clinical Medicine & Research. 2011
  • Medication adherence in patients with uncontrolled blood pressure: results from the Hyperlink Study [abstract]
    Clinical Medicine & Research. 2011
  • PS1-31: Assessing the potential for research on genetics of drug induced liver injury in the HMORN [abstract]
    Clinical Medicine & Research. 2011
  • Participant characteristics associated with medication adherence [abstract]
    Journal of Managed Care Pharmacy. 2011
  • Patient characteristics associated with medication adherence [abstract]
    Clinical Medicine & Research. 2011
  • Validation of genomic markers that predict distant recurrence risk via FISH assays in women with early stage breast carcinoma [abstract]
    Journal of Clinical Oncology. 2007
  • presentations
    Presentation
  • Age, comorbidity and breast cancer severity - their impact on receipt of guideline therapy and rate of recurrence among older women with early stage breast cancer [presentation], HMO Research Network 17th Conference: Collaborations in Population-Based Health Research
  • Applying a model to predict neutropenia risk in patients with cancer using electronic data [presentation], HMO Research Network (HMORN) 21st Annual Conference: Care Improvement Research: Partnering with Patients, Providers and Operational Leaders
  • Applying a neutropenia risk model to cancer patients using VDW data: a CRN pilot study [presentation], HMO Research Network (HMORN) 21st Annual Conference: Care Improvement Research: Partnering with Patients, Providers and Operational Leaders
  • Barriers and facilitators for medication adherence [presentation], HMO Research Network 17th Conference: Collaborations in Population-Based Health Research
  • Cancer research in your community [webinar]
  • Clinical pharmacy productivity metrics: developing an automated tool [presentation]
  • Clinical pharmacy productivity metrics: the journey to develop a useful clinical decision-making tool [presentation]
  • Collaborating with HealthPartners and the HMO Cancer Research Network: a new opportunity [presentation]
  • Collaborating with the CRN: an overview and examples of adherence research [presentation]
  • Disparities in oral capecitabine use: a chart review of older patients treated in the community [presentation], HMO Research Network 20th Annual Conference: Embedded Research to Improve Health
  • Gender disparities in capecitabine dosing: findings from a chart review of older patients treated in the community [presentation]
  • HOPA (Hematology Oncology Pharmacist Association) 2015 clinical pearls: geriatric oncology [presentation]
  • Junctions, crossorads, and roundabouts: the intersection between polypharmacy and drug interactions in geriatric oncology [presentation]
  • New drug update: investigational products [presentation]
  • Osteoporotic fracture risk among long-term survivors of breast cancer diagnosed at older ages [presentation], HMO Research Network (HMORN) 18th Annual Conference--Learning Health Care Systems: Leading Through Research
  • Pain scores, analgesic utilization, and patient satisfaction among cancer patients at a community cancer center [presentation]
  • Primary non-adherence and health care utilization [presentation], HMO Research Network 17th Annual Conference: Collaborations in Population-Based Health Research
  • Proton pump inhibitor use and the risk of adverse cardiovascular events in aspirin-treated patients with coronary artery disease [presentation]
  • The CRN Scholars Program: training for research in integrated systems [presentation], HMO Research Network (HMORN) 21st Annual Conference: Care Improvement Research: Partnering with Patients, Providers and Operational Leaders
  • The application of real-world evidence to biosimilars [presentation], Academy of Managed Care Pharmacy (AMCP) Nexus 2017 Conference
  • Using VDW data for individual- and population-level pharmacy outcomes [presentation]
  • Utilizing Cancer Research Network clinial and administrative electronic data to improve cancer care [presentation]
  • Contact
    primary email
  • Pamala.A.Pawloski@HealthPartners.Com
  • located in facility
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