Charlene E. McEvoy, MD, MPH
Clinical Investigator
About

Title: Clinical investigator; staff physician, Pulmonary Critical Care Department, Regions Hospital; medical director, Hudson Hospital Sleep Lab, Hudson, WI; medical director, Asthma Center, HealthPartners Specialty Center, St. Paul, MN; medical director, Regions Hospital/HealthPartners Sleep Center, Maplewood, MN; medical director, Regions/HealthPartners Home Medical Equipment, St. Paul.

Assistant professor of medicine, University of Minnesota, Minneapolis.

Education and training: MD, MPH, University of Minnesota; Residency in internal medicine, University of Minnesota Medical School, Minneapolis; Chief medical resident, Ramsey Medical Center, St. Paul, MN; Fellowship in pulmonary and critical care medicine, University of Minnesota Medical School, Minneapolis; Fellowship in allergy, University of Minnesota Medical School, Minneapolis; Archibald Bush Medical Fellowship, Bush Foundation.

Overview/research interests: Dr. McEvoy’s research interests include COPD and other smoking-related disorders, asthma and sleep disorders.

Current projects:

  • COPD Gene Renewal. Funder: National Heart, Lung and Blood Institute
  • A MultiCentre, Randomized, Double-blind, Parallel Group, Placebo-Controlled, Phase III Efficacy and Safety Study of Benralizumab (MEDI-563) Added to High-Dose Inhaled Corticosteroid Plus Long-Acting β2 Agonist in Patients with Uncontrolled Asthma (SIROCCO) and (BORA – open label). Funder: AstraZeneca Pharmaceuticals
  • A Safety and Efficacy Study of Inhaled Fluticasone Propionate/Salmeterol Combination versus Inhaled Fluticasone Propionate in the Treatment of Adolescent and Adult Subjects with Asthma (AUSTRI TRIAL). Funder: GlaxoSmithKline
  • A 24-Week Randomized Double-Blind Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of 18 MCG of Tiotropium Inhalation Capsules Administtered by Handihaler Once-Daily Plus PRN Albuteral (Salbutamol) vs. Placebo Plus PRN Albuterol (Salbutomol) in Chronic Obstructive Pulmonary Disease Subjects Naïve to Maintenance Therapy (SPIRIVA). Funder: Pfizer Inc., U.S. Pharmaceuticals Group
  • Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma (PAS2). Funder: Boston Scientific
  • Longitudinal Follow-Up to (1 of 2) Genetic Epidemiology of COPD. Funder: COPD Foundation
Affiliation
positions
  • Sr. Investigator, Vaccines
  • Clinical Investigator, Pulmonology
  • Publications While At Healthpartners
    selected publications
    Journal Article
  • A randomised trial of anti-GM-CSF Otilimab in severe COVID-19 pneumonia (OSCAR)
    European Respiratory Journal. 2023
  • Accuracy of COVID-19-like illness diagnoses in electronic health record data: retrospective cohort study
    JMIR formative research. 2023
  • Effectiveness of COVID-19 vaccines at preventing emergency department or urgent care encounters and hospitalizations among immunocompromised adults: an observational study of real-world data across 10 US states from August-December 2021
    Vaccine. 2023
  • Estimation of COVID-19 mRNA vaccine effectiveness and COVID-19 illness and severity by vaccination status during Omicron BA.4 and BA.5 sublineage periods
    JAMA network open. 2023
  • Protection of two and three mRNA vaccine doses against severe outcomes among adults hospitalized with COVID-19--VISION Network, August 2021 to March 2022
    Journal of Infectious Diseases. 2023
  • Vaccine effectiveness against influenza-associated urgent care, emergency department, and hospital encounters during the 2021-2022 season, VISION Network
    Journal of Infectious Diseases. 2023
  • Bronchial thermoplasty in patients with severe asthma at 5 years: the Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma study
    Chest. 2022
  • Bronchodilators in tobacco-exposed persons with symptoms and preserved lung function
    New England Journal of Medicine. 2022
  • Early estimates of bivalent mRNA vaccine effectiveness in preventing COVID-19-associated emergency department or urgent care encounters and hospitalizations among immunocompetent adults - VISION Network, nine states, September-November 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of 2, 3, and 4 COVID-19 mRNA vaccine doses among immunocompetent adults during periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 sublineages predominated - VISION Network, 10 states, December 2021-June 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of COVID-19 mRNA vaccines against COVID-19-associated hospitalizations among immunocompromised adults during SARS-CoV-2 Omicron predominance - VISION Network, 10 states, December 2021-August 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of a third dose of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during oeriods of Delta and Omicron variant predominance - VISION Network, 10 states, August 2021-January 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of homologous and heterologous COVID-19 booster doses following 1 Ad.26.COV2.S (Janssen [Johnson & Johnson]) vaccine dose against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults - VISION Network, 10 states, December 2021-March 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults-nine states, January-September 2021
    American Journal of Transplantation. 2022
  • Promoting chronic obstructive pulmonary disease wellness through remote monitoring and health coaching: a clinical trial
    Annals of the American Thoracic Society. 2022
  • Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during periods of Delta and Omicron variant predominance - VISION Network, 10 states, August 2021-January 2022
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study
    BMJ (Clinical research ed.). 2022
  • Chronic bronchitis in COPD patients creates worse symptom burden regardless of the presence of bronchiectasis in the COPDGene cohort
    Chronic obstructive pulmonary diseases (Miami, Fla.). 2021
  • Effectiveness of 2-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults - nine states, January-September 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Laboratory-confirmed COVID-19 among adults hospitalized with COVID-19-like illness with infection-induced or mRNA vaccine-induced SARS-CoV-2 immunity - nine states, January-September 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 vaccine
    New England Journal of Medicine. 2021
  • Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials
    The Lancet. Respiratory medicine. 2021
  • COPDGene(®) 2019: redefining the diagnosis of chronic obstructive pulmonary disease
    Chronic obstructive pulmonary diseases (Miami, Fla.). 2019
  • Effect of health coaching delivered by a respiratory therapist or nurse on self-management abilities in severe COPD: analysis of a large randomized study
    Respiratory Care. 2019
  • Metoprolol for the prevention of acute exacerbations of COPD
    New England Journal of Medicine. 2019
  • Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD)
    Respiratory Research. 2017
  • Health coaching in severe COPD after a hospitalization: a qualitative analysis of a large randomized study
    Respiratory Care. 2017
  • Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies
    European Respiratory Journal. 2017
  • Severe polyserositis induced by the 13-valent pneumococcal conjugate vaccine: a case report
    2017
  • Health coaching and chronic obstructive pulmonary disease rehospitalization. a randomized study
    American Journal of Respiratory and Critical Care Medicine. 2016
  • High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial
    International Journal of Chronic Obstructive Pulmonary Disease. 2016
  • Clinical and radiologic disease in smokers with normal spirometry
    JAMA internal medicine. 2015
  • Implementation of physical activity programs after COPD hospitalizations: lessons from a randomized study
    Chronic Respiratory Disease. 2015
  • Self-reported sleep quality and acute exacerbations of chronic obstructive pulmonary disease
    International Journal of Chronic Obstructive Pulmonary Disease. 2015
  • Healthcare utilization and costs in persons with insomnia in a managed care population
    American Journal of Managed Care. 2014
  • Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma
    Journal of Allergy and Clinical Immunology. 2013
  • Development and feasibility of a self-management intervention for chronic obstructive pulmonary disease delivered with motivational interviewing strategies
    Journal of Cardiopulmonary Rehabilitation and Prevention. 2013
  • Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy
    COPD. 2012
  • Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease
    Clinical Infectious Diseases. 2012
  • Azithromycin for prevention of exacerbations of COPD
    New England Journal of Medicine. 2011
  • Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study
    American Journal of Respiratory and Critical Care Medicine. 2011
  • Epidemiology, radiology, and genetics of nicotine dependence in COPD
    Respiratory Research. 2011
  • Lung volumes and emphysema in smokers with interstitial lung abnormalities
    New England Journal of Medicine. 2011
  • Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    COPD. 2011
  • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    American Journal of Respiratory and Critical Care Medicine. 2010
  • AIR2Trial: bronchial thermoplasty for asthma: changing the landscape for future treatment
    Advance for Managers of Respiratory Care. 2007
  • Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease
    American Journal of Respiratory and Critical Care Medicine. 1998
  • Abstract
  • Post-approval study for bronchial thermoplasty (BT): results to 2 years [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2017
  • Sleep quality in patients with moderate to severe COPD [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2014
  • Pilot study of sleep disturbance and lung disease in older adults [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2010
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