When you're living with diabetes, heart disease, asthma, arthritis or other long-term conditions, keeping track of medications, attending appointments, managing costs and adjusting to changes can feel overwhelming.

By recognizing how chronic conditions can affect mental health, you can take steps to support both your body and mind and know when it may be time to reach out for help.

What is the connection between chronic illness and mental health?

It's common for people living with chronic conditions to experience stress, anxiety or depression. But many don't realize how strongly mental and physical health can influence each other.

Here's why living with a chronic illness can impact mental health so profoundly.

Feelings of grief after a diagnosis are common

When you're diagnosed with a chronic illness, there may be routines, activities or future plans that look different now or may no longer be possible. It's natural to sometimes feel a sense of loss and to worry about what's ahead.

Everyday tasks may take more energy

Fatigue, discomfort or mobility challenges may make it harder to do things independently or stay involved in activities that once brought you joy. It's understandable to feel frustrated and discouraged when your condition affects your daily routine and independence, or when you’re in frequent discomfort.

Frequent appointments and time away from work can create financial stress

Living with a chronic illness often comes with added expenses and unexpected challenges. Taking time off for appointments, treatments or symptom flare-ups can affect your ability to work and earn income. And concerns about medical costs and insurance coverage can create ongoing worry, making it even harder to manage your overall well-being.

Some medications can cause mental health side effects

Some medications used to treat chronic conditions can affect your mood, energy levels or sleep, which may contribute to symptoms of stress, anxiety or depression.

Social isolation can affect emotional well-being

Social connection plays an important role in mental health. When chronic health challenges make staying connected harder, the risk of depression and anxiety increases.

Chronic conditions that can affect mental health

People living with chronic conditions experience higher rates of depression and anxiety. Ongoing conditions that can lead to mental health challenges include:

  • Arthritis
  • Cancer
  • Chronic pain
  • Chronic obstructive pulmonary disease (COPD) and other respiratory conditions
  • Diabetes (Type 1 and 2)
  • Heart disease
  • Obesity

How mental health can affect chronic disease management

Living with a chronic condition can be challenging on its own. When depression, anxiety or ongoing stress is added to the mix, managing your health can feel even more difficult, making it harder to:

  • Attend appointments and follow treatment plans
  • Stay on track with healthy habits like exercising and eating well
  • Take medications consistently and correctly
  • Monitor symptoms and track changes in your condition
  • Communicate with your care team about concerns and treatment needs

Taking care of your mental health can improve your health overall

Your mental and physical health are closely connected. When you're feeling emotionally supported, it's often easier to stay engaged in your care and make choices that support your health and well-being.

Getting help for depression, anxiety or other mental health concerns can improve your quality of life and make managing a chronic condition feel less overwhelming. Over time, even small steps toward better emotional health can make a meaningful difference in how you feel and how you manage your condition day to day.

Condition management support for body, mind and spiritOur condition management support services can help coordinate your care, offer expert advice and much more.

People living with chronic illness are more likely to experience depression

The everyday challenges of managing symptoms, keeping up with treatments and adjusting to life changes can take an emotional toll. That's why it isn’t unusual for people with chronic health conditions to experience depression or other mental health concerns.

Research shows that:

  • People with diabetes are twice as likely to experience depression
  • 18-45% of people with cardiovascular disease (heart attack/stroke) experience symptoms of depression
  • 40% of adults with chronic pain also live with depression and/or anxiety
  • 27% of people with chronic respiratory diseases like COPD experience symptoms of depression
  • People living with obesity have a 55% greater risk of developing depression
  • 30-35% of cancer patients or survivors experience symptoms of depression
  • 26% of people with chronic kidney disease experience symptoms of depression

Remember, depression isn’t a sign of weakness, and there is help available to you. If feelings of sadness or hopelessness or loss of interest in activities last for more than a few weeks, talk with your doctor or a mental health professional. Support and treatment are available and can make a meaningful difference.

Self-care tips for living with a chronic illness and depression

Self-care isn’t a replacement for medical or mental health treatment, but healthy habits can support both your physical and emotional well-being. Start small and focus on progress, not perfection.

Physical activity can help improve mood and reduce stress. Even a short walk, gentle stretching or chair exercises can make a difference.


Aim for a consistent sleep schedule and create a bedtime routine that helps you unwind. Quality sleep supports both physical healing and emotional resilience.


Stay connected with friends, family members, support groups or others who understand what you're going through. You don't have to manage everything on your own.


Break larger health goals into smaller, achievable steps. Celebrating small wins can help you build confidence and feel less overwhelmed.


Deep breathing, mindfulness, meditation, journaling or spending time outdoors can help lower stress and improve emotional well-being.


Make time for hobbies and activities that bring you a sense of purpose, enjoyment or connection, even if you need to modify them to fit your current abilities.


Social media has its benefits, but spending too much time scrolling can affect your mental health. Consider setting limits on your social media use or taking regular breaks to support your well-being.


Taking medications as prescribed and keeping appointments can help you feel more in control of your health and support better outcomes.


Living with a chronic condition can be difficult. Try to treat yourself with the same compassion and patience that you would offer a loved one.


Mental health is an important part of your overall healthWe’re here to connect you with resources, specialists and support to get you back on the road to feeling and living better.

Signs that stress, anxiety or depression may be affecting your health

It's normal to feel stressed, worried or discouraged from time to time. But when those feelings don't go away or begin to affect your daily life, it may be a sign that you need additional support. Watch for signs like:

  • Changes in your appetite or losing weight without trying
  • Difficulty concentrating, remembering things or making decisions
  • Feeling like your health condition is harder to manage because of stress, anxiety or low mood
  • Feeling more irritable, frustrated or emotional than usual
  • Feeling sad, hopeless or overwhelmed most of the day, nearly every day
  • Losing interest in activities you once enjoyed
  • Low energy or ongoing fatigue that doesn't improve with rest
  • Sleeping too much, having trouble falling asleep or waking frequently during the night
  • Withdrawing from friends, family or social activities
  • Worrying constantly or feeling unable to relax

Talk with your doctor if symptoms last more than a few weeks or begin affecting your daily life or health

If you're experiencing any of these symptoms, know that you're not alone. Many people living with chronic conditions experience periods of increased stress, anxiety or depression, and help is available.

Your primary care doctor can help identify what's contributing to your symptoms and connect you with the right support. This may include a referral to a therapist or mental health specialist, recommendations for self-care strategies, or discussing whether medication could be helpful. Addressing concerns early can make a meaningful difference in both your emotional well-being and your overall health.

HealthPartners resources that can help you manage stress, anxiety or depression

Managing a chronic condition is easier when you have the right support. If you’re a HealthPartners member, you have access to additional resources and activities to help with your emotional health and well-being:

  • Behavioral health navigators – Call 952-883-5811 or 888-638-8787 to get compassionate assistance finding a mental or chemical health care professional in your current plan network.
  • Condition management support services – Get personalized resources, guidance and assistance.
  • Living Well – Build healthier habits, reduce stress and improve your mood with personalized activities.
  • Mental Health Hub – Find information, tools and support for you and your family. You’ll also find resources to explore your plan benefits, get care and more.
  • Teladoc Mental Health – Improve your health and well-being with access to hundreds of activities, articles and videos, all at no cost.

Included with most HealthPartners plans: