Elyse O. Kharbanda, MD, MPH
Executive Director, Research
"Investing in the health and well-being of pregnant people, children, and adolescents is key to understanding and ultimately preventing chronic diseases in adult populations. My research covers a range of topics in maternal and child health including vaccination in pregnancy, pediatric hypertension, and adolescent risk behavior screening."
About

Dr. Elyse Olshen Kharbanda is Executive Director of Research and a Senior Research Investigator at HealthPartners Institute. Dr. Kharbanda is a board-certified pediatrician with subspecialty board certification in adolescent medicine. Since joining the Institute in 2010, Dr. Kharbanda has led an impactful portfolio of research, leveraging health system data to promote health care quality for women and children.

Dr. Kharbanda leads the HealthPartners Institute Vaccine Safety Datalink (VSD) team. In collaboration with the Centers for Disease Control and Prevention and several other health systems, the VSD conducts post-licensure safety surveillance for vaccine in use in the United States. Dr. Kharbanda and her HealthPartners-based VSD team have and continue to lead multisite observational studies of vaccines administered during pregnancy, with publications in JAMA, NEJM and MMWR. Data from these studies has been widely disseminated, including through presentations to the Advisory Committee on Immunization Practices (ACIP).

A second area of focus for Dr. Kharbanda has been the use of point-of-care electronic data capture and clinical decision support (CDS) to improve care for children and adolescents. With funding from the National Institute of Health (NIH), Dr. Kharbanda developed and implemented an electronic health record linked CDS to improve recognition and early management of hypertension in adolescents. This tool has been implemented across the HealthPartners care delivery system and with funding from the Agency for Healthcare Research and Quality (AHRQ) is now being adapted and implemented in Essentia Health. Dr. Kharbanda has also helped in the development and validation of the pediatric appendicitis risk calculator (pARC) and has piloted a tool for electronic capture of adolescent risk screening.

Dr. Kharbanda completed her medical degree at Albert Einstein College of Medicine, pediatric residency at New York Presbyterian Hospital, Columbia University and adolescent fellowship at Boston Children’s Hospital and Boston Medical Center. She received a Master’s in Public Health from Columbia University and was an Assistant Professor of Pediatrics and Public Health at Columbia University prior to joining the Institute.

Joined the Institute: 2010

Education and training: MD, Albert Einstein College of Medicine; MPH, Mailman School of Public Health, Columbia University.

Overview/research interests: Vaccine and drug safety and pregnancy, clinical decision support, teen pregnancy, and interventions to promote vaccine uptake.

Current research activities and funding:

  • Vaccine Safety Datalink
  • EHR-Based Clinical Decision Support to Improve BP Management in Adolescents (Peds and TeenBP)
  • EHR-Based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care (Appy CDS)
  • Adolescent risk behavior screening (eTeenQ)
Affiliation
positions
  • Sr. Investigator, Center for Chronic Care Innovation 2010 -
  • Sr. Research Investigator, Vaccines 2010 -
  • Sr. Research Investigator, Pregnancy and child health 2010 -
  • Senior Research Investigator, MD, Primary care, pediatrics 2010 -
  • Executive Director, Research, HealthPartners Institute 2021 -
  • Publications
    selected publications
    Journal Article
  • Antibiotics prior to age 2 years have limited association with preschool growth trajectory
    International Journal of Obesity (2005). 2022
  • Association of the COVID-19 pandemic with routine childhood vaccination rates and proportion up to date with vaccinations across 8 US health systems in the Vaccine Safety Datalink
    JAMA pediatrics. 2022
  • Evaluation of acute adverse events after Covid-19 vaccination during pregnancy
    New England Journal of Medicine. 2022
  • Gestational diabetes mellitus is associated with altered abundance of exosomal microRNAs in human milk
    Clinical Therapeutics. 2022
  • Gestational diabetes mellitus is associated with differences in human milk hormone and cytokine concentrations in a fully breastfeeding United States cohort
    Nutrients. 2022
  • How to make up for rotavirus vaccination missed during the COVID-19 pandemic?-Reply
    JAMA pediatrics. 2022
  • Influenza vaccination during pregnancy and risk of selected major structural noncardiac birth defects, National Birth Defects Prevention Study 2006-2011
    Pharmacoepidemiology and Drug Safety. 2022
  • Monitoring vaccine safety using the vaccine safety Datalink: assessing capacity to integrate data from Immunization Information systems
    Vaccine. 2022
  • Point: uncertainty about estimating the risks of COVID-19 during pregnancy
    Paediatric and Perinatal Epidemiology. 2022
  • Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birth - eight integrated health care organizations, United States, December 15, 2020-July 22, 2021
    MMWR: Morbidity and Mortality Weekly Report. 2022
  • Risk of myocarditis and pericarditis following BNT162b2 and mRNA-1273 COVID-19 vaccination
    Vaccine. 2022
  • Safety of COVID-19 vaccination in United States children ages 5 to 11 years
    Pediatrics. 2022
  • "I know my body better than you:" patient focus groups to inform a decision aid on oral corticosteroid use during pregnancy
    Pharmacoepidemiology and Drug Safety. 2021
  • Association of inadvertent 9-valent human papillomavirus vaccine in pregnancy with spontaneous abortion and adverse birth outcomes
    JAMA network open. 2021
  • COVID-19 vaccination coverage among insured persons aged ≥16 years, by race/ethnicity and other selected characteristics - eight integrated health care organizations, United States, December 14, 2020-May 15, 2021
    MMWR: Morbidity and Mortality Weekly Report. 2021
  • Developing algorithms for identifying major structural birth defects using automated electronic health data
    Pharmacoepidemiology and Drug Safety. 2021
  • Effect of clinical decision support on diagnostic imaging for pediatric appendicitis: a cluster randomized trial
    JAMA network open. 2021
  • Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings
    New England Journal of Medicine. 2021
  • Human milk glucose, leptin, and insulin predict cessation of full breastfeeding and initiation of formula use
    Breastfeeding Medicine. 2021
  • Incidence of pediatric inflammatory bowel disease within the Vaccine Safety Datalink network and evaluation of association with rotavirus vaccination
    Vaccine. 2021
  • Infant sex differences in human milk intake and composition from 1- to 3-month post-delivery in a healthy United States cohort
    Annals of Human Biology. 2021
  • Maternal dietary intake of total fat, saturated fat, and added sugar is associated with infant adiposity and weight status at 6 mo of age
    Journal of Nutrition. 2021
  • Spontaneous abortion following COVID-19 vaccination during pregnancy
    JAMA. 2021
  • Surveillance for adverse events after COVID-19 mRNA vaccination
    JAMA. 2021
  • Temporal trends in undervaccination: a population-based cohort study
    American Journal of Preventive Medicine. 2021
  • The childhood vaccination schedule and the lack of association with type 1 diabetes
    Pediatrics. 2021
  • Vaccine Safety Datalink infrastructure enhancements for evaluating the safety of maternal vaccination
    Therapeutic advances in drug safety. 2021
  • Association between rotavirus vaccination and type 1 diabetes in children
    JAMA pediatrics. 2020
  • Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy
    Journal of Perinatology. 2020
  • Clinical decision support for recognizing and managing hypertensive blood pressure in youth: no significant impact on medical costs
    Academic Pediatrics. 2020
  • Diagnostic performance of emergency physician gestalt for predicting acute appendicitis in patients age 5 to 20 years
    Academic Emergency Medicine. 2020
  • Effects of the COVID-19 pandemic on routine pediatric vaccine ordering and administration - United States, 2020
    MMWR: Morbidity and Mortality Weekly Report. 2020
  • Evaluating the association of stillbirths after maternal vaccination in the Vaccine Safety Datalink
    Obstetrics and Gynecology. 2020
  • Improving hypertension recognition in adolescents, a small but important first step in cardiovascular disease prevention
    Academic Pediatrics. 2020
  • SARS-CoV-2 infection among hospitalized pregnant women: reasons for admission and pregnancy characteristics - eight U.S. health care centers, March 1-May 30, 2020
    MMWR: Morbidity and Mortality Weekly Report. 2020
  • Association of full breastfeeding duration with postpartum weight retention in a cohort of predominantly breastfeeding women
    Nutrients. 2019
  • Development of a clinical decision support system for pediatric abdominal pain in emergency department settings across two health systems within the HCSRN
    EGEMS (Washington, DC). 2019
  • Higher maternal diet quality during pregnancy and lactation is associated with lower infant weight-for-length, body fat percent, and fat mass in early postnatal life
    Nutrients. 2019
  • Impact of updated pediatric hypertension guidelines on progression from elevated blood pressure to hypertension in a community-based primary care population
    Journal of Clinical Hypertension (Greenwich, Conn.). 2019
  • Maternal antibiotic use during pregnancy and childhood obesity at age 5 years
    International Journal of Obesity (2005). 2019
  • Relationship of maternal weight status before, during, and after pregnancy with breast milk hormone concentrations
    Obesity (Silver Spring, Md.). 2019
  • Safety of guidelines recommending live attenuated influenza vaccine for routine use in children and adolescents with asthma
    Vaccine. 2019
  • Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders
    Vaccine. 2019
  • Text message alerts to emergency physicians identifying potential study candidates increase clinical trial enrollment
    Journal of the American Medical Informatics Association. 2019
  • Uptake and safety of hepatitis A vaccination during pregnancy: a Vaccine Safety Datalink study
    Vaccine. 2019
  • Validation of the Pediatric Appendicitis Risk Calculator (pARC) in a community emergency department setting
    Annals of Emergency Medicine. 2019
  • Clinical decision support for recognition and management of hypertension: a randomized trial
    Pediatrics. 2018
  • Development and validation of a novel Pediatric Appendicitis Risk Calculator (pARC)
    Pediatrics. 2018
  • Evaluation of an electronic clinical decision support tool for incident elevated BP in adolescents
    Academic Pediatrics. 2018
  • Infant hospitalizations and mortality after maternal vaccination
    Pediatrics. 2018
  • Racial disparities in family-provider interactions for pediatric asthma care
    Journal of Asthma. 2018
  • Risk of spontaneous abortion after inadvertent human papillomavirus vaccination in pregnancy
    Obstetrics and Gynecology. 2018
  • Uptake and safety of Hepatitis B vaccination during pregnancy: a Vaccine Safety Datalink study
    Vaccine. 2018
  • Febrile seizure risk after vaccination in children one to five months of age
    Pediatric Neurology. 2017
  • First trimester influenza vaccination and risks for major structural birth defects in offspring
    Journal of Pediatrics. 2017
  • Identifying birth defects in automated data sources in the Vaccine Safety Datalink
    Pharmacoepidemiology and Drug Safety. 2017
  • Immunization: Vaccine Safety Datalink
    Minn Physician. 2017
  • Maternal Tdap vaccination and risk of infant morbidity
    Vaccine. 2017
  • Maternal and infant outcomes after human papillomavirus vaccination in the periconceptional period or during pregnancy
    Obstetrics and Gynecology. 2017
  • Spontaneous abortion and ectopic pregnancy: case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data
    Vaccine. 2017
  • Change in weight status and development of hypertension
    Pediatrics. 2016
  • Congenital anomalies: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data
    Vaccine. 2016
  • Febrile seizure risk after vaccination in children 6 to 23 months
    Pediatrics. 2016
  • Implementation of electronic clinical decision support for pediatric appendicitis
    Pediatrics. 2016
  • Influenza vaccination during pregnancy: influenza seasons 2002-2012, Vaccine Safety Datalink
    American Journal of Preventive Medicine. 2016
  • Maternal Tdap vaccination: coverage and acute safety outcomes in the vaccine safety datalink, 2007-2013
    Vaccine. 2016
  • Mismatching among guidelines, providers, and parents on controller medication use in children with asthma
    The journal of allergy and clinical immunology. In practice. 2016
  • Potential misclassification of blood pressure status in children and adolescents with short or tall stature
    American Journal of Epidemiology. 2016
  • Risk of anaphylaxis after vaccination in children and adults
    Journal of Allergy and Clinical Immunology. 2016
  • Risk of preterm or small-for-gestational-age birth after influenza vaccination during pregnancy: caveats when conducting retrospective observational studies
    American Journal of Epidemiology. 2016
  • Tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring
    JAMA. 2016
  • Vaccination and 30-day mortality risk in children, adolescents, and young adults
    Pediatrics. 2016
  • Association of Tdap vaccination with acute events and adverse birth outcomes among pregnant women with prior tetanus-containing immunizations
    JAMA. 2015
  • Asthma treatments and mental health visits after a Food and Drug Administration label change for leukotriene inhibitors
    Clinical Therapeutics. 2015
  • Comparing US paediatric and adult weight classification at the transition from late teenage to young adulthood
    Pediatric Obesity. 2015
  • Factors associated with adherence to blood pressure measurement recommendations at pediatric primary care visits, Minnesota and Colorado, 2007-2010
    Preventing Chronic Disease. 2015
  • Impacting delayed pediatric influenza vaccination: a randomized controlled trial of text message reminders
    American Journal of Preventive Medicine. 2015
  • Primary adherence to controller medications for asthma is poor
    Annals of the American Thoracic Society. 2015
  • Safety of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis and influenza vaccinations in pregnancy
    Obstetrics and Gynecology. 2015
  • TeenBP: development and piloting of an EHR-linked clinical decision support system to improve recognition of hypertension in adolescents
    EGEMS (Washington, DC). 2015
  • A comparison of confounding adjustment methods for assessment of asthma controller medication effectiveness
    American Journal of Epidemiology. 2014
  • Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes
    JAMA. 2014
  • Impact of hypertension on healthcare costs among children
    American Journal of Managed Care. 2014
  • Influenza vaccine text message reminders for urban, low-income pregnant women: a randomized controlled trial
    American Journal of Public Health. 2014
  • Influenza vaccine: an updated position statement of the Society for Adolescent Health and Medicine
    Journal of Adolescent Health. 2014
  • Initiation of oral contraceptives and changes in blood pressure and body mass index in healthy adolescents
    Journal of Pediatrics. 2014
  • Lipid screening in children and adolescents in community practice: 2007 to 2010
    Circulation: Cardiovascular Quality and Outcomes. 2014
  • Maternal influenza vaccine and risks for preterm or small for gestational age birth
    Journal of Pediatrics. 2014
  • Missed opportunities for pregnancy prevention among insured adolescents
    JAMA pediatrics. 2014
  • Monovalent H1N1 influenza vaccine safety in pregnant women, risks for acute adverse events
    Vaccine. 2014
  • Prevalence of obesity and extreme obesity in children aged 3-5 years
    Pediatric Obesity. 2014
  • Receipt of pertussis vaccine during pregnancy across 7 Vaccine Safety Datalink Sites
    Preventive Medicine. 2014
  • Severe obesity in children: prevalence, persistence and relation to hypertension
    International Journal of Pediatric Endocrinology. 2014
  • Use of leukotriene receptor antagonists are associated with a similar risk of asthma exacerbations as inhaled corticosteroids
    The journal of allergy and clinical immunology. In practice. 2014
  • Vaccinations given during pregnancy, 2002-2009: a descriptive study
    American Journal of Preventive Medicine. 2014
  • Adolescent consent for vaccination: a position paper of the Society for Adolescent Health and Medicine
    Journal of Adolescent Health. 2013
  • Current status and future prospects for electronic point-of-care clinical decision support in diabetes care
    Current Diabetes Reports. 2013
  • Identifying pregnancy episodes, outcomes, and mother-infant pairs in the Vaccine Safety Datalink
    Vaccine. 2013
  • Inactivated influenza vaccine during pregnancy and risks for adverse obstetric events
    Obstetrics and Gynecology. 2013
  • Influenza and pertussis vaccination coverage among privately insured women of reproductive age
    Maternal and child health journal. 2013
  • Maternal safety of trivalent inactivated influenza vaccine in pregnant women
    Obstetrics and Gynecology. 2013
  • Patterns of care and persistence after incident elevated blood pressure
    Pediatrics. 2013
  • Prehypertension and hypertension in community-based pediatric practice
    Pediatrics. 2013
  • Receipt of human papillomavirus vaccine among privately insured adult women in a U.S. midwestern health maintenance organization
    Preventive Medicine. 2013
  • Safety of the yellow fever vaccine: a retrospective study
    Journal of Travel Medicine. 2013
  • Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use
    American Journal of Respiratory and Critical Care Medicine. 2013
  • Effect of a text messaging intervention on influenza vaccination in an urban, low-income pediatric and adolescent population: a randomized controlled trial
    JAMA. 2012
  • Identifying adolescent females at high risk of pregnancy in a pediatric emergency department
    Journal of Adolescent Health. 2012
  • Text4Health: impact of text message reminder-recalls for pediatric and adolescent immunizations
    American Journal of Public Health. 2012
  • Delivering adolescent preventive services in an office setting
    Adolescent Medicine: State of the Art Reviews. 2011
  • Exploring pregnant women's views on influenza vaccination and educational text messages
    Preventive Medicine. 2011
  • Text message reminders to promote human papillomavirus vaccination
    Vaccine. 2011
  • The role of human papillomavirus vaccination in promoting delivery of other preventive and medical services
    Academic Pediatrics. 2011
  • Changes in Tdap and MCV4 vaccine coverage following enactment of a statewide requirement of Tdap vaccination for entry into sixth grade
    American Journal of Public Health. 2010
  • Vaccinating teens: current guidelines, challenges, and opportunities
    Pediatric Annals. 2010
  • Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009
    MMWR: Recommendations and Reports. 2009
  • Conference Poster
  • Elevated blood pressure and risks for progression to hypertension in youth 10-17 years of age [poster]
    2019
  • Development and validation of a risk equation for appendicitis in children presenting with abdominal pain [poster]
    2017
  • Racial/ethnic disparities in completion of the routine immunization series by age two [poster]
    2017
  • Results of a cluster-randomized trial testing the effects of TeenBP, an EHR-based clinical decision support tool, on recognition of adolescent hypertension [poster]
    2017
  • Incident ADHD diagnosis and use of stimulant medication among youth 10-17 years [poster]
    2015
  • Relation of change in weight status to the development of hypertension in children and adolescents [poster]
    2015
  • Implementation of a pediatric prehospital pain management protocol [poster]
    2014
  • Diagnosis of pediatric hypertension depends on clinical practice guideline definitions [poster]
    2013
  • Frequency and results of glucose screening in children and adolescents 2007-2011 [poster]
    2013
  • Impact of BMI and change in BMI on progression from normotension to prehypertension or hypertension in patients ages 3-17 [poster]
    2013
  • Impact of oral contraceptives on adolescent blood pressure and BMI [poster]
    2013
  • Impact of oral contraceptives on adolescent blood pressure and BMI [poster]
    2013
  • Prehypertension and hypertension in community-based pediatric practice [poster]
    2013
  • Prevalence of obesity and extreme obesity in children aged three to five years [poster]
    2013
  • Acute adverse events following trivalent inactivated influenza vaccine (TIV) in pregnancy [poster]
    2012
  • Baseline blood pressure among adolescents initiating hormonal contraception [poster]
    2012
  • Pregnancy among insured adolescents [poster]
    2012
  • Estimating pregnancy start dates with prenatal procedure codes [poster]
    2011
  • Intentions for pregnancy among female adolescents presenting to a pediatric emergency department [poster]
    2011
  • Safety of seasonal influenza vaccine (TIV) in pregnant women [poster]
    2011
  • Safety of the yellow fever vaccine: a retrospective study [poster]
    2011
  • Abstract
  • Pediatric appendicitis: trends in emergency department imaging and outcomes in the community setting, 2010-2015 [abstract]
    Annals of Emergency Medicine. 2016
  • Relation of change in weight status to the development of hypertension in children and adolescents [abstract]
    Journal of patient-centered research and reviews. 2016
  • Glucose screening and identification of pre-diabetes in children and adolescents 2007-2011 [abstract]
    Diabetes. 2013
  • Leukotriene inhibitors may be more effective than inhaled corticosteroids in preventing asthma-related exacerbations [abstract]
    American Journal of Respiratory and Critical Care Medicine. 2013
  • A descriptive study of vaccinations occurring during pregnancy, 2002-2006 [abstract]
    Clinical Medicine & Research. 2012
  • Identifying pregnancy episodes in the Vaccine Safety Datalink [abstract]
    Clinical Medicine & Research. 2012
  • Prevalence of HT in children: comparison between task force recommendations and average of multiple measurements over 2 or 4 years [abstract]
    Clinical Medicine & Research. 2012
  • Prevalence of elevated blood pressure and BMI in U.S. children and adolescents [abstract]
    Clinical Medicine & Research. 2012
  • HMORN research on pediatric hypertension and obesity: predictors, care, and costs: design of a new pediatric cohort [abstract]
    Clinical Medicine & Research. 2011
  • Overweight and obesity in those age 3-17 years old: implications for diabetes prevention [abstract 2377-PO]
    Diabetes. 2011
  • Prevalence of overweight and elevated blood pressure in a large cohort of children and adolescents (age 3-17 years) at an initial clinic examination [abstract]
    Journal of Clinical Hypertension (Greenwich, Conn.). 2011
  • presentations
    Presentation
  • Association of BMI and change in BMI on progression from normotension to prehyertension or hypertension in patients ages 3-17 [presentation]
  • Association of BMI and change in BMI on progression from normotension to prehypertension or hypertension in patients ages 3-17 [presentation], Minnesota Health Services Research 17th Annual Conference
  • Disparities in pregnancy and birth rates among insured adolescents, 2003-2010 [presentation]
  • Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes [presentation]
  • FluText: using text messaging to promote timely flu vaccination in an underserved child population [presentation]
  • FluText: using text messaging to promote timely flu vaccination in an underserved child population [presentation], National Immunization 45th Conference
  • Maternal receipt of trivalent inactivated influenza vaccine and risks for preterm or small for gestational age birth [presentation], HMO Research Network 19th Annual Conference: Advancing Research in the Era of Healthcare Reform
  • Patterns of blood pressure measurement at pediatric primary care visits in large medical group practices [presentation], Minnesota Health Services Research 15th Annual Conference
  • Safety of COVID-19 vaccination in pregnancy - interim data from the Vaccine Safety Datalink [presentation]
  • Safety of the seasonal influenza vaccine during pregnancy: maternal health outcomes [presentation]
  • Specialty differences in recognizing and managing elevated blood pressures among children and adolescents [presentation]
  • Specialty differences in recognizing and managing elevated blood pressures among children and adolescents [presentation]
  • Tdap during pregnancy: safety and coverage data from the VSD [presentation]
  • Use of electronic clinical decision support to improve clinical recognition of incident elevated blood pressure and return for repeat measurement [presentation]
  • Contact
    full name
  • Elyse O. Kharbanda, MD, MPH
  • primary email
  • Elyse.O.Kharbanda@HealthPartners.Com
  • located in facility
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